PRIMARY NEROENDOCRINE SMALL CELL CARCINOMA OF THE BREAST RARE PATHOLOGY- CASE REPORT.

Small cell neuro-endocrine tumors (NETS) are uncommon and mostly occur in Lung and Gastrointestinal tract while extra pulmonary NETS are rare. Primary small cell carcinoma of the breast is rare entity and less than 40 cases have been reported in the literature worldwide. Diagnosis of primary small cell carcinoma of breast requires histopathological evaluation and positivity of the immunohistochemical stains like synaptophysin and chromogranin and ruling out primary from other sites as well. Standard treatment guide lines have not been yet established because of the rarity of this tumor. Most of the patients reported in the literature have been treated by surgery, chemotherapy, radiotherapy and hormonal therapy for patients whose tumor was estrogen and progesterone receptor positive. We present a case of 60 years old female patient of primary small cell carcinoma of the breast. Investigations were done to rule out any other lesion in the body. She has been staged as IIIB according to TNM staging. She is getting neoadjuvant chemotherapy with significant clinical response.