27May 2019

PLASMA MAGNESIUM STATUS IN DIABETIC PATIENT WITH RETINOPATHY.

  • Department of internal medicine,Faculty of medicine , Benha University , Egypt.
  • Department of Ophthalmology, Faculty of medicine ,Benha University , Egypt.
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Background: Hypomagnesaemia has been reported to occur with increased frequency in patients with type 2 diabetes mellitus; it is frequently overlooked and undertreated. Hypomagnesemia has also been associated with diabetic retinopathy. Aim of the work: : The present study was conducted with an objective to evaluate the plasma magnesium in type 2 Diabetes mellitus cases. The present study also attempts to evaluate the possible relationship between diabetic retinopathy and plasma magnesium levels. Patients and methods:In this study 50 type 2 diabetic patients with age group of 30 to70 years were included and divided into 3 groups.group I included diabetic patients with PDR,group II included diabetic patients with NPDR and group III included diabetic patients without retinopathy.all cases were subjected to estimate biochemical parameters in form of RBS,plasma magnesium level ,HbA1c and kidney function tests ,plus fundus examination. In this study we exclude patients with renal failure,patients with acute myocardial infarction in last six months,patients on diuretics or on magnesium supplementation or magnesium containing antacid ,mala absorption syndrome,chronic diarrhea and patients with history of alchol abuse. Results: The comparative study consists of 9 diabetic patient with proliferative diabetic retinopathy( group I), 21 diabetic patient with non proliferative diabetic retinopathy (groupII) and 20 diabetic patient with out diabetic retinopathy(group III). The average range of plasma Magnesium level among 3 groups was 1.36?0.26, 1.62?0.26 and 1.86?0.20 respectively, There is significant difference among 3 group(P< 0.05), low level of plasma magnesium with group I (proliferative diabetic retinopathy) and high level with group III(with out retinopathy).Conclusion: The serum magnesium levels were significantly lower in patients with diabetic retinopathy compared to diabetics without complications.

  1. KingH,AubertRE,HermanWH,eta,(1998):Globalburdenof diabetes,1995-2025.Diabetes-care;21:1414-31.
  2. AmericanDiabetesAssociation(2014):Diagnosisandclassificationof diabetesmDiabetescare ;(suppl.1):S81-S90 .
  3. MaltezosE,PapazoglouD,ExiaraT,e,(2004):Serummagnesium levelsinnondiabeticoffspringofpatientswithtype2diabetes mellitus. DiabetesNutrMetab;17:12-6.
  4. Whang R,Ryder KW(1990):Frequency???????? of??????????? hypomagnesemJAMA;263:3063-64
  5. DasguptaA,SarmaD,SaikiaKU(2012):Hypomagnesemiaintype2 diabetesmellitus,IndianJEndocrinolMetab.;16(6):1000-
  6. GroftonG,Borter(1992):TheroleofmagnesiumindiabetesmellJ Diabetescomplications;6;143-149.
  7. 7-DelvaP,DeganM,PastoriC,etal.,(2002):Glucose-induced alterationsofintracellularionizedmagnesiuminhuman lymphocytes.
  8. WaltiMK,ZimmermannMB,SpinasGA,etal.,(2003):Lowplasma magnesiumintype2diabeteDiabetescare ;133:346-355.
  9. Mohamed MurtuzaKauser, AsfiaAfreen, KasiJagadeesh M(2014):Study of Serum Magnesium Levels in Diabetic Retinopathy ,Journal of Research in Medical and Dental Science eISSN No. 2347-2367 pISSN No. 2347-2545
  10. Hadad,SalahZuhair (2010),serum magnesium and severity of diabetic retinopathy.The medical journal of BasrahUniversity,vol 28,No.1
  11. BaigM,AliM.Study of serum magnesium in diabetic
  12. Inj J Biol MedRes2012;3(4):2480-2482.
  13. KareemI,JaweedSA,etal.,(2004):Studyofmagnesium,glycosylated hemoglobinandlipidprofileindiabeticretinopathy.Indialjournal;19(2):124-
  14. SharmaA,DablaS,AgarwalRPe,(2007):Serummagnesium;An earlypredictorofcourseandcomplicationsofdiabetesmellitus. MedAssoc;105:16-20.
  15. Hatwal A1,?Gujral AS,?Bhatia RP,?Agrawal JK,?Bajpai HS(1989).
  16. Association of hypomagnesemia with diabetic retinopathy.
  17. ActaOphthalmol (Copenh).1989 Dec;67(6):714-6.
  18. ValkHW,HardusPLLJ, VanRijn ,et al., (1999): Plasma magnesiumconcentrationandprogressionof retinopathy.Diabetescare ;22:864-

[Wafaa Kamel Abd El-moniem, Fawzy Megahed Khalil, Ramy Ahmed Samy, Ahmed Mohamed Hussein Dabour and Marwa Abdelshafy. (2019); PLASMA MAGNESIUM STATUS IN DIABETIC PATIENT WITH RETINOPATHY. Int. J. of Adv. Res. 7 (May). 973-983] (ISSN 2320-5407). www.journalijar.com

Wafaa Kamel Abd El monem.

DOI:

Article DOI: 10.21474/IJAR01/9122      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9122

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