CURCUMIN INDUCED APOPTOSIS VIA G2/M ARREST IN HUMAN OVARIAN CANCER CELLS.

The goal of this study carried out to investigate suppression ability by curcumin against proliferation of ovarian cancer cells. When curcumin was treated for 0, 24, and 48 h from 0 to 90 ?M concentrations, PA-1 cells were discovered by decreased survival ratio depending on the concentration and time. The IC50 concentrations from 24 and 48 h-treated cells were found to 19.7 and 4.4 ?M, respectively. To investigate the function of curcumin on cell cycle, PA-1 cells treated with 5 ?M curcumin were observed with FACS at 24 and 48 h. As a result, a number of cells in G1 stage of cycle increased depending on the elapsed times, and caused G2/M arrest. Therefore, it is assumed that curcumin plays an effective role in ovarian cancer cells as an antiproliferative agent via G2/M arrest.