A COMPREHENSIVE REVIEW ON HABITAT OF MICROBIAL COMPARISON BETWEEN NORMAL ORAL CAVITY AND PATIENTS HAVING ORAL CANCERS.

There are numerous bacterial species within human body, of which several are unknown. A major habitation of bacteria including micro-floras and opportunistic pathogens are present in the oral cavity. Our purposes were :(i) types of bacterial species present in the normal oral cavity of human; (ii) types of opportunistic pathogens present in the oral cavity; (iii) Chances of the pathogens to initiate an oral cancer; (iv) comparative study between the bacteria in normal cavity and patients having oral cancers. Some bacteria may cause infections depending on preferable conditions. Infections include inflammation, sensitivity, redness, and some may have carcinogen mutated genes. Infections causing inflammations may be the most consequential preventable cause of oral cancer. Microbial populations on mouth mucosa differ between salubrious and malignant sites. Approximately, 87-90% of the oral cancer throughout the World. Certain oral bacterial species are also linked with malignancies due to their ability to induce chronic inflammation. Different bacteria have been proposed to induce carcinogenesis either through induction of chronic inflammation or by interference, either directly or indirectly, with eukaryotic cell cycle and signalling pathways, or by metabolism of potentially carcinogenic substances. The vicissitudes in micro-flora on oral mucosa commence after cancerous alteration, due to change in pH, irregularity of lesion surface and broken bulwark mechanism of the oral mucosa. This may lead both local and systemic infections because of debilitated immune system by chemotherapy, irradiation, and surgery.