Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene?

Cancer is a genome disease, initiated by mutations in genes that usually control cell growth and division. Matrix metalloproteinases (MMPs) have important roles in both of tumor invasion and spread. The present study was conducted to evaluate the effect of ionizing radiation (in the level of treatment doses of ?-rays). The action of collagenase gene was examined in vivo by using a model of solid tumor carcinoma (EAC). Eighty male mice were used for this experiment; it is divided into 8 groups, 10 mice / each; which were Normal, beside three groups of normal mice and three groups of tumor transplanted mice each of them exposed to the following accumulated doses (6, 9 and12 Gy). Whole body mice were exposed to gamma radiation from Cobalt-60 (60Co) twice a week for three weeks with different doses after 12 days of injected ehirlich tumor in the right thigh region. The different doses of ionizing radiation exposure resulting in different changes (Mutations) on the sequence of collagenase gene in normal and malignant implanted groups and the level of these mutations were height in the malignant groups.