EFFECTS OF ADMINISTRATION OF ETHANOLIC EXTRACT OF GANODERMA LUCIDUM ON ARTERIAL BLOOD PRESSURE OF NORMOTENSIVE CATS.
- Department of Human Physiology, Faculty of Medicine, Kaduna State University, Nigeria.
- Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University Zaria, Nigeria.
- Department of Anatomy, Faculty of Medicine, Kaduna State University, Nigeria.
- Department of Biological Sciences, Faculty of Pure and Applied Sciences, Federal University Wukari, Nigeria.
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The fruiting bodies ethanol extact of Ganoderma lucidum of the family Ganodermataceae was evaluated for arterial blood pressures lowering effects in normotensive cats. The effects of each dose of extract on the arterial blood pressure (BP) of normotensive cats were studied. The extract exhibited a significant (p<0.05) dose-dependent depression of blood pressure in normotensive cats between 1, 10 and 50 mg/ml. It produces a decrease in systolic blood pressure (p<0.05 value). It also exhibited a decrease in diastolic pressure which was significant (p<0.05) at all three doses. On mean arterial blood pressure (MABP), Ganoderma lucidum has a decreasing effect, which is statistically significant. The activities of the extract were comparable to that of other reference drugs: propranolol, Ach, and Atropine sulphate.The intravenous LD50 value of the extract was 12.89 mg/kg body weight in mice (MEDEP, 2008).The results obtained from the present studies supported the traditional claim that the plant is used in the management of hypertension in human.
[A.D.T. Goji, J.A. Tende, D.S. Amaza and I. Ezekiel. (2016); EFFECTS OF ADMINISTRATION OF ETHANOLIC EXTRACT OF GANODERMA LUCIDUM ON ARTERIAL BLOOD PRESSURE OF NORMOTENSIVE CATS. Int. J. of Adv. Res. 4 (Nov). 20-32] (ISSN 2320-5407). www.journalijar.com
