FORMULATION AND EVALUATION OF AZILSARTAN KAMEDOXOMIL FAST DISSOLVING TABLETS.

The purpose of this work was to formulate and prepare fast dissolving tablets of azilsartan kamedoxomil which is practically insoluble drug for improving its poor oral bioavailability and with the aim of alleviating administration to patients facing problems with swallowing. Tablets were prepared adopting effervescent and sublimation techniques. Ac-Di-Sol, explotab, crospovidone and glycine were used as superdisintigrants along with blend of sodium bicarbonate, citric acid (as effervescent mixture) and menthol and ammonium carbonate (as sublimating agents). The mixture was directly compressed using Avicel PH 102, Sorbitab and lactose fast flow as diluent. Pre-compression parameters such as bulk density, tapped density, bulkiness, compressibility (Carr's index), Hausner ratio and angle of repose were evaluated. Post-compression parameters such as weight variation, content uniformity, hardness, friability, disintegration time, in-vitro dispersion time, wetting time, water absorption ratio and in vitro dissolution were performed and compared to commercially product Edarbi® 40mg tablets. Results revealed that SD2, SD3, SD4, EF4 and EF6 could increase amount of azilsartan kamedoxomil dissolved to more than 80% within 10min. Stability studies were performed on the selected formulae namely; SD2, SD3, SD4, EF4, EF6 and Edarbi® 40mg tablets. The physicochemical properties of stored tablets were performed