GREEN APPROACH TOWARDS SYNTHESIS OF 3-SUBSTITUTED-5-CARBONYLMETYL-1,2,4-OXADIAZOLES WITHOUT ANY SOLVENT AND CATALYST VIA TRANSAMIDOXIMATION.
- Discovery Centre, Process Technology Development Division, Defence R. & D. Establishment, Jhansi Road, Gwalior – 474002 (M.P), India.
- Department of Chemistry, Kommuri Pratap Reddy Institute of Technology, Hyderabad - 501301 (TS), India.
- Abstract
- Keywords
- Cite This Article as
- Corresponding Author
An efficient, simple, environmentally benign, cost-effective and expeditious etiquette for the construction of biologically momentous 3-substituted-5-carbonylmetyl-1,2,4-oxadiazole derivatives in one-pot has been developed by the reaction of methyl ?-ketoesters with an assortment of amidoximes via transamidoximation transformation, which further experience intramolecular cyclization followed by dehydration at 110°C. The current environmentally benign protocol offers the advantages of simple methodology, cost-efficiency, short reaction times, neat reaction profiles without solvent and catalyst shows a novel direction in green synhesis along with great yield.
[G. B. Dharma Rao and Ravi Gujjula. (2016); GREEN APPROACH TOWARDS SYNTHESIS OF 3-SUBSTITUTED-5-CARBONYLMETYL-1,2,4-OXADIAZOLES WITHOUT ANY SOLVENT AND CATALYST VIA TRANSAMIDOXIMATION. Int. J. of Adv. Res. 4 (Sep). 416-422] (ISSN 2320-5407). www.journalijar.com
