ASSESSMENT OF SOME IMMUNOLOGICAL ASPECTS IN IMMUNODEFICIENCY PATIENTS WITH BACTERIAL SKIN INFECTION.

The main objective of the study was to determine the difference in immune response between the two groups of patients suffering from bacterial skin infections, where the first group included 50 Immunodeficiency patients while the second group was 50 non immunodeficiency patients. The first step of this study consisted of isolating the bacterial species responsible for skin infections in the two groups were isolated 43 bacterial isolation distributed among the 28(65.1%) isolates of the first group and 15(34.9%) isolates of the second group . Staphylococcus aureus Psudomonase auregenosa had the highest isolation rate , reaching 24(55%) and 10(23.8%) respectively, in addition to that the highest proportion of bacterial isolate has been recorded in the cancer patients10 (35.7%) than in the rest Immunodeficiency cases. There is no significant increase in the total number of white blood cells with marked rise in neutrophil cells only in immunodeficiency patients groups with skin infection compared with immunodeficiency patients groups without skin infection as well as with the control group and there is a decrease in the level of C3 in most studied groups except cancer patients compared to control group. While a concentration of C4 showed no significant increase in both normal and immunodeficiency immune system patients with skin infections except kidney failure patients compared to control group. There was significant increase in the level of IL- 33 in immunodeficiency patients with skin infection compared to other patients groups, especially patients with diabetes and renal failure, While there was clearly a significant decrease in the level of IL-27 in the studied groups compared to the control group, but increased in immunodeficiency patients with skin infection compared with normal immune system and skin infections patients as well as the present results showed that there is a clear rise in the level of TNF- in the serum of all patients groups under study compared to the control.