ZEIN NANOPARTICLE AS SAFE EFFECTIVE BIOCOMPATIBLE NANOCARRIER
- Department of Biochemistry and Molecular biology, Faculty of Pharmacy Helwan University.
- Department of Pharmaceutics and Industrial pharmacy, Faculty of Pharmacy Cairo University.
- Department of Biochemistry and Molecular biology, Faculty of Medicine Cairo University.
- Abstract
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- Corresponding Author
Zein nanoparticles (ZNPs) is protein nanoparticles (NPs) that can effectively carry wide range of both hydrophobic and hydrophilic drugs. ZNPs was formulated by coaservation method that is considered as very advantageous regarding simplicity and safety as no harmful materials were used in the preparation. The safety pattern of this NPs so that it can be used without any hazard in human is an urgent concern that should be studied deeply. This study revealed that ZNP is a safe NPs with excellent biocompatibility and minimal toxicity toward viable cells that confirmed by invitro cytotoxic analysis of HepG2 cell lines using neutral red assay. In conclusion, our findings suggested that this natural protein nanomaterials is very biocompatible with no toxicity toward viable cells.
[Shaimaa Mohammed Ewais, Rania Hassan Fahmy, Laila Ahmed Rashid and Fathia Zaki El-Sharkawi. (2016); ZEIN NANOPARTICLE AS SAFE EFFECTIVE BIOCOMPATIBLE NANOCARRIER Int. J. of Adv. Res. 4 (Sep). 1814-1817] (ISSN 2320-5407). www.journalijar.com
