A CORRELATIVE STUDY OF SERUM INORGANIC PHOSPHATE CONCENTRATION AND FASTING BLOOD GLUCOSE IN TYPE 2 DIABETES MELLITUS – A HOSPITAL BASED STUDY.

Objective: 1. To study serum inorganic phosphate concentration and fasting blood glucose in patients with type 2 diabetes mellitus. 2. To find the correlation between serum inorganic phosphate level and fasting blood glucose in patients with type 2 diabetes mellitus. Materials and methods:- The study was carried out on 50 newly diagnosed patients of type 2 diabetes and controls in the Department of Biochemistry, Assam medical college, Dibrugarh. Analysis of blood glucose (fasting and postprandial), serum inorganic phosphate, urea and creatinine concentrations were performed by standard methods using semi automated analyser. Results:- Concentrations of fasting and postprandial blood glucose higher in the diabetic group than controls (p<0.01). The mean serum inorganic phosphate concentration in cases was found to be significantly lower than controls (2.68±0.56 vs 3.64±0.42 mg/dl) and p < 0.01. Present study revealed an inverse relationship between serum inorganic phosphate concentration and fasting blood glucose in patients with type 2 Diabetes Mellitus with a correlation coefficient, r = - 0.67 substantiated by regression analysis. Conclusion:- There is definite reduction of serum inorganic phosphate concentration in type 2 Diabetes Mellitus patients and that reduction of serum inorganic phosphate concentration may have a contributing role in the progression of the disease and development of complications of diabetes.