CORRELATION BETWEEN SERUM VITAMIN D LEVEL AND PULMONARY FUNCTION (FEV1) IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE(COPD).

Background:- Evidence suggests that vitamin D has role apart from its classic action on bone and calcium homeostasis. Vitamin D deficiency associated with pulmonary function deterioration. Aims: The present study was done with the following aims & objectives. 1. To measure the serum 25-Hydroxy vitamin D status in patient with COPD with acute exacerbation and compare it with stable COPD state. 2. To assess the relationship between serum 25-Hydroxy vitamin D in patients with stable COPD and Forced expiratory volume in 1st second (FEV1) in patients with COPD. Methods:- From November 2013 to September 2015 fourtysix consecutive patients with COPD presented to our outdoor and indoor of Pulmonary medicine VSS Medical College entered to the study.Serum 25-OHD was assessed by Electrochemolminescence Immunoassay method and postbrochodilator forced expiratory volume in 1s (FEV1) was measured in all patients. Serum vitamin D was categorized as deficient (< 20 ng/ml),Insufficient ( ?20 ng/ml to < 30ng/ml) and Sufficient (? 30 ng/ml). The mean values of FEV1 for each class of serum 25-OHD were determined and compaired. Results:- The mean age of patients was 65.5±5.42 years. The mean serum 25-OHD level in A/E of COPD state was 21.32±4.73ng/ml and in stable COPD state was 25.72±5.15ng/ml. On correlating the serum vitamin D level and FEV1% of predicted in stable COPD patients , in 25OHD deficiency COPD cases FEV1% of predicted was 28.10±6.17,in 25-OHD insufficiency cases was 35.92±8.03 and sufficiency case was 46.10±11.99. There was very strong positive correlation present between, serum 25-OHD and FEV1 % of predicted in stable COPD with Pearson correlation coefficient r= 0.742591,p value <0.001. Conclusion:- Low serum vitamin D is common among COPD patients and is more in acute exacerbation of COPD state. There was very strong positive correlation present between, serum 25-OHD and FEV1.