Does n-3 polyunsaturated fatty acids diet affect the lipolytic activity of adipose tissue in insulin resistant rats?

The association between abdominal fat accumulation and risk of multiple chronic diseases has been established. Insulin resistance is the hallmark mechanism unifying obesity, dyslipidemia, hyperglycemia, diabetes, hypertension and cardiovascular diseases. This study investigates the effect of n-3 polyunsaturated fatty acids diet on the outcomes of insulin resistant rats as well as the lipolytic activity of adipose tissue. n-3 polyunsaturated fatty acids enriched diet for 3 months showed a significant reduction in body weight (BW) , systolic blood pressure ( SBP) , triglyceride, cholesterol, LDL, fasting blood glucose (FBG) and insulin levels in insulin resistant rat with a significant rise in HDL level and lipolytic activity of both SC and visceral adipose tissue.