PREHYPERTENSION ;THE POINT OF CONVERGENCE OR DIVERGENCE FOR END ORGAN DAMAGE

Background and Aim of work:- In hypertensive people, left ventricular hypertrophy (LVH) can anticipate an expanded morbidity & sudden death, which is up to ten times more common in people with left ventricular hypertrophy (LVH) than those without. To investigate the extent to which prehypertension may be associated with preclinical target organ damage (TOD) so we comprehensively investigated the association of prehypertension with parameters of left ventricular (LV) structure and function . Patients& methods:- This prospective study was carried out in cardiology department, Zagazig University in the period from August 2014 to October 2015. This study included two groups classified by ambulatory BPmonitoring (ABPM) to exclude masked hypertension and by serial office blood pressure measurement :Prehypertensive (G1) and control (G11). Result:- Compared to participants with optimal BP, those with prehypertension had a nominally higher prevalence of abnormal LV geometry increased left ventricular mass index (LVMI) cutoff point of QT dispersion > 40 ms indicate presence of increased LVMI with sensitivity =76.26 &specificity =57.78 The mean adjusted LV mass was significantly greater in prehypertensive(193.65+41.14 g/m2 vs. 159+35.56; p<0.001). Conclusion:- Increased efforts regarding education, detection, and treatment could be important in management ofpre hypertension and cardiovascular disease risk prevention.