THE AGING BRAIN: NANOTECHNOLOGY SOLUTIONS WITH DIAGNOSTIC METHODS AND RECENT ADVANCES.

Alzheimer’s disease (AD) is the leading cause of dementia is a devastating degenerative disease of brain that results in progressive cognitive impairment and functional disability. AD lacks definite diagnostic approaches and effective cure at the present. Moreover, the currently available diagnostic tools are not sufficient for an early screening of AD in order to start preventive approaches. Recently the emerging field of nanotechnology has promised new techniques to solve some of the AD challenges. In this review, we present the promises that nanotechnology brings in research on the AD diagnosis ,Proposed invitro and invivo nanodiagnostic approaches, Nanoformulations investigated and therapy through nanotechnology. Applications of nanotechnology in AD therapy including neuroprotections against oxidative stress and anti-amyloid therapeutics, neuroregeneration and drug delivery beyond the blood brain barrier (BBB) are discussed and analyzed. All these applications could improve the treatment approach of AD and other neurodegenerative diseases. The complete cure of AD may become feasible by a combination of nanotechnology and some other novel approaches, like stem cell technology.