Investigation of Inflammatory Markers (IL-6 and hs-CRP) in Type1 Diabetes Patients

The present study was designed to investigate the levels of interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) as an inflammatory markers and an association between these markers with the body mass index (BMI) and with the level of glycated hemoglobin (HbA1c) in type1 diabetes patients. Ninety one blood samples were collected from type1 diabetes patients and healthy individuals in a period between June and the end of November 2012 at the AL-Kindy Specialized Center for Diabetes and Endocrinology and the Central Child Hospital , their ages ranged between (1 - 18 year), they are divided into three groups ,newly diagnosed, chronic and healthy control groups .IL-6 and hs-CRP were done by using ELISA , while HbA1c was done by using spectrophotometer. The results showed that there are significant differences between diabetic patients and non diabetic groups of study (p ? 0.05), highly significant was demonstrated in hs-CRP and IL-6 tests in chronic patients and newly diagnosed patients at mean 9.42 ± 1.28 mg/L and 6.53 ± 2.29 pg/ml respectively .The correlation between hs-CRP and IL-6 with biomass(BMI) ,fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) was non significant ,there was ( r= - 0.036 , 0.077,and r = 0.064 ) for hs-CRP respectively , and ( r = 0.022 , 0.90, and r = 0.119) for IL-6 respectively. This study concludes that the circulating levels of inflammatory markers were elevated in patients with T1D and their levels were not affected by glycated hemoglobin A1c and BMI