NEURAL TISSUE ENGINEERING.

Various problems and complications arise while doing treatment of severe nerve injuries with conventional methods such as Autologous Nerve Grafting, Allograft and Xenografts. Recent advancements in nerve regeneration have involved the application of tissue engineering principles and this has evolved a new perspective to neural therapy. Tissue Engineering (TE) basically makes use of a combination of cells, growth factors and scaffolds to improve or replace injured tissues. Scaffolds are basically analogous to ECM (Extra Cellular Matrix) and it can support 3D growth of nerve or any other cell type. An ideal scaffold is biocompatible, less inflammatory, doesn’t produce toxic degradation products and porous (for vascularization and cell migration). This review paper is about the various principles required for fabrication of scaffold for neural tissue engineering.