LE SURDOSAGE ET ACCIDENTS AUX AVK : ETUDE CAS TEMOIN : A PROPOS DE 400 PATIENTS

Introduction: occurrence of bleeding is the most feared complication of warfarin and prevention remains a key concern in monitoring. The purpose of this study is to identify the characteristics of patients with severe accidents AVK and its management. Material and Methods: We conducted a prospective study of 100 patients conducted in the cardiology department chu Mohamed VI in Marrakech from Mai 2014 to Mai 2016. Résultat: The average age of our patients is 55 sex ratio of 1, 27. Atrial fibrillation was the main indication identified. Gastrointestinal bleeding origin was the most frequent in 60% of cases. The majority of patients experienced at least one bleeding risk factor: age in 30% of cases, the biological overdose of INR 80% of cases, drug interactions in 10% of cases of hypertension in 40 % of cases, cerebrovascular diseases in 13% of cases and the antecedent of bleeding in 10%. 60% of our patients did not have a good biological monitoring based INR default means. The emergency conduct was based on the cessation of AVK, the administration saw K, transfusion of packed red cells and fresh frozen plasma. The average hospital stay is 2 days Conclusion: The prognosis The AVK is one of the most effective treatments. However, their handling is difficult and the risk of bleeding complications is present. The new oral anticoagulants offer another alternative.