30Jan 2017

ASSOCIATION BETWEEN PRIMARY SITE OF MELANOMA AND SURVIVAL OF U.S. ADULT PATIENTS

  • Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Saudi Arabia.
  • Florida International University (FIU), United States.
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Introduction:Melanoma is the most dangerous form of skin cancer. The National Cancer Instituteestimated that there would be 76,100 new invasive melanoma cases and 9,710 deaths from melanoma in the US in 2014. Anatomic location was identified as a significant prognostic factor in patients with primary cutaneous melanoma (CM) by several investigators. Objectives: The aim of this study is to assess the relationship betweenprimary site of melanoma and survival in a large US adult population. Materials & methods: We analyzed 227,509 US melanoma patients from the SEER (Surveillance, Epidemiology, and End Results ProgramRegistry) from 1973 to 2011. We excluded duplicate cases.We compared the primary site and survival by using Kaplan-Meier curves. Hazard ratio (HR) were determined by unadjusted and adjusted Cox-regression model. Results: In the unadjusted model, the primary anatomical site was significantly associated with survival. Melanoma patients who had a primary site as an overlapping lesion of skin (the tumor overlaps the boundaries of two or more adjacent anatomical sites) were 10 times more likely to die within 5 years of diagnosis compared topatientswithnon-overlapping lesions located on the head or neck (HR= 10.7, 95%CI=10.3 - 11.1). After we adjusted for age at diagnosis, gender, race, ethnicity andstage at diagnosis, patients with overlapping lesion of skin still had lower chance of surviving more than 5 years as compared to patients with non-overlapping head and neck lesions, followed by trunk (HR= 3.5, 95%CI= 3.3 - 3.6 and HR=1.2, 95%CI= 1.2 - 1.3, respectively). Conclusions: Overlapping lesion of skin had the worst prognosis followed by trunk lesions, while lesions located atupper limbs & shoulders had better prognosis. Clinical correlation and timely diagnosis of primary melanoma sites might improve survival and prognosis in this population.

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[Algarni Ali,Al-OmariNaif, Acuna Juan and Sami Aldaham. (2017); ASSOCIATION BETWEEN PRIMARY SITE OF MELANOMA AND SURVIVAL OF U.S. ADULT PATIENTS Int. J. of Adv. Res. 5 (Jan). 2066-2073] (ISSN 2320-5407). www.journalijar.com

ALI ALGARNI
Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Saudi Arabia

DOI:

Article DOI: 10.21474/IJAR01/2978      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2978

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