INTRAPERITONEAL BUPIVACAINE FOR POSTOPERATIVE PAIN RELIEF AFTER LAPAROSCOPIC CHOLECYSTECTOMY

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Pain is defined as “an un-pleasant sensory and emotional experience associated with actual or potential tissue damage”.Laparoscopic cholecystectomy is now an established form of treatment for patients with symptomatic gallstones. Recent studies have shown that patients may experience considerable pain after laparoscopic cholecystectomy. The various methods used with variable success are NSAID’S, infiltration of wound with local anesthetics and intermittent intramuscular narcotics. In Laproscopic Cholecystectomy after removal of gall bladder from the abdominal cavity using an endobag the position of the patient was made supine and 0.25% of 10 ml bupivacaine was instilled in the gall bladder fossa under direct laparoscopic control in Group A patients while Group B patients did not receive any such solution.Group A showed less intensity of pain with time duration as compared to Group B. A descriptive analysis of the VAS pain scores was in table 1. Statistically significant stepwise decrease in pain score at 4 hrs, 8 hrs, 12 hrs and 24 hrs were found in Group A and B. Intraperitoneal bupivacaine for laparoscopic cholecystectomy in a dose of 10 ml of 0.25% rather than using a higher dose reduces pain in the initial postoperative period and also in first 24 hrs, it is easy to administer with no adverse effects and may become a routine practice for this procedure.


  1. Merskey H. Pain terms: A list with definitions and notes on usage recommended by the IASP subcommittee on taxonomy. Pain1979;6:249-52.
  2. Morely S. Vivid memory for every day pains. Pain 1993; 55:55-62.
  3. Alessandri F, Lijoy D, Mistrangelo E et al. Effects of presurgical local infiltration of levobupivicane in the surgical field on post surgical wound pain in laparoscopic gynecological surgery. ActaObstetGynecol Scand 2006; 85:844-9.
  4. Rademaker BM, Ringers J, Odoom JA et al. Pulmonary function a stress response after laparoscopic cholecystectomy: comparison with subcostal incision and influence of thoracic epidural anaesthesia. Anesthesia and Analgesia 1992; 75: 381-385.
  5. Joris J, Cigarini, I, Legrand M, Jacquet N et al. Metabolic and respiratory changes after cholecystectomy performed via laparotomy or laparoscopy.Brit J Anaesth 1992; 69: 341-345
  6. Lord Mc Coll. Laparoscopic cholecystectomy. Am R collSurgEngl: 1992;74:231
  7. Rees BI, Williams HR. Laparoscopic Cholecystectomy the first 155 patients. Am R CollSurg Eng 1992; 74:233-236.
  8. Scott AND, Greville AC, Mc Millan L et al.Laparoscopic laser cholecystectomy results of the technique in 210 patients Am R CollSurg; 1992; 74: 237 – 241.
  9. Narchi P, Benhamou D, Fernandez H. Intraperitoneal local anaesthetic for shoulder pain after day case laparoscopy. The Lancet 1991; 338: 1569-1570.
  10. Chundrigar T, Morris R, Hedges AR et al. Intraperitoneal bupivacaine for effective pain relief after laparoscopic cholecystectomy. Annals R collsurgEngl; 1993;75:437-439.
  11. Scheinin B, Kellokiempu I, Lindgren L et al. Effect of intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy. ActaAnaesthesia Scand; 1995;39: 195-198.
  12. Pasqualucci A, Angelis VA, Contrado R et al. PreenptiveAnagesiaIntraperitoneal local anaesthetic in laparoscopic cholecystectomy. A randomised, double blind, placebo controlled study. Anesthesiology 1996; 85: 11-20.
  13. Khan SA, Butt K, Chaudhry ZA, S Mushtaq A, Experience with 0.5% Bupivacaine Pro-peritoneal Bleb.after laparoscopic cholecystectomy – A new Trend in analgesia. Ann King Edward Med Coll. 2000;6(4):359-60.
  14. Chundrigar T, Hedges AR, Morris R et al. Intraperitoneal bupivacaine for effective pain relief after laparoscopic cholecystectomy. Ann R CollSurgEngl 1993;75:437–9.
  15. Rademaker BM, Kalkman CJ, Odoom JA, et al. Intraperitoneal local anaesthetics after laparoscopic cholecystectomy: effects on postoperative pain, metabolic responses and lung function. Br J Anaesth 1994;72:263–6.
  16. Louizos AA, Hadzilia SJ, Leandros E et al. Postoperative pain relief after laparoscopic cholecystectomy.SurgEndosc. 2005;19:1503-6.
  17. Verma GR, Lyngdoh TS, Kaman L et al. Placement of 0.5% bupivacaine soaked surgicel in the gall bladder bed is effective for pain after laparoscopic cholecystectomy. Surg.Endosc.2006;20:1560-4.
  18. Karaaslan D, Sivaci RG, Akbulut G et al. Preemptive analgesia in laparoscopic cholecystectomy: a randomized controlled study. Pain Pract. 2006;6:237-41.
  19. Tariq GR, Mian MA, Chaudhry IA.Comparision of inrtaperitoneal analgesia with bupivacaine/bupivacaine with ketorolac after laparoscopic cholecystectomy. J Surg Pak 2004;9:9-13.
  20. Mraovi? B,  Jurisi?  T,  Kogler-Majeric  V et al. Intraperitonealbupivacaine for analgesia aft er laparoscopic    Acta Anaesthesiol Scand.1997Feb;41(2):193-6.
  21. Khan RA ,WaseemN,etal,The effectiveness of intra operative wound infiltration with long acting LocalAnesthetic. J Postgrad Med Inst,Nov-Jan 2002;16(1):26-8.
  22. Moiniche S, Jorgensen H, Wetterslev J et al. Local anesthetic infiltration for postoperative pain relief aft er laparoscopy: a qualitative and quantitative systematic review of intraperitoneal, port-site infiltration and mesosalpinxblock.AnesthAnalg 2000;90:899–912.
  23. Szem JW, Hydo L, Barie PS. A double blind evaluation of intraperitoneal bupivacaine vs saline for the reduction of postoperative pain and nausea after laparoscopic cholecystectomy.SurgEndosc. 1996; 10: 44–48.
  24. Cunniff e MG, McAnena OJ, Calleary J et al. A prospective randomized trial of intraperitoneal bupivacaine irrigation for management of shoulder-tip pain following laparoscopy. Am J Surg. 1998;176:258–261.
  25. Tsimoyiannis EC, Glantzounis G, Lekkas ET, et al. Intraperitoneal normal saline and bupivacaine infusion for reduction of postoperative pain after laparoscopic cholecystectomy.SurgLaparoscEndosc 1998;8:416–20.
  26. Aman Z.,QayumAet al . A study of effectiveness of local Bupivacaine infiltration of the wound in reducing the post operative parenteral narcotic analgesic requirement. J Postgrad Med Inst Jan-Mar2004;18(1):7-11.
  27. Scheinin, B., Kellokumpu,I., Lindgren, L.et al. Effect of intraperitoneal bupivacaine on pain after laparoscopic cholecystectomy. ActaAnaesthesiologicaScandinavica, 1995, 39:195–198.
  28. Bhardwaj N, Sharma V, Chari P.INTRAPERITONEAL BUPIVACAINE INSTILLATION FORPOSTOPERATIVE PAIN RELIEF AFTER LAPAROSCOPICCHOLECYSTECTOMY. Indian journal of anesthesia; 46(1): 49-52.
  29. Wasim M, Shafqatullah S M, Subhan A. Role of intraperitoneal bupivacaine in laparoscopicCholecystectomy. Pak J Surg 2014; 30(3):222-226.

Gurmeet Singh, Athar Parvez, Digamber Chaubey, Ajay Verma and K. B. Jain. (2017); INTRAPERITONEAL BUPIVACAINE FOR POSTOPERATIVE PAIN RELIEF AFTER LAPAROSCOPIC CHOLECYSTECTOMY, Int. J. of Adv. Res., 5 (02), 2607-2611, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/3449


Dr Gurmeet Singh
VIVEKANANDA POLYCLINIC & INSTITUTE OF MEDICAL SCIENCES, LUCKNOW

DOI:


Article DOI: 10.21474/IJAR01/3449      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3449