28Feb 2017

ANTIMICROBIAL ANALYSIS OF SCHIFF BASE LIGANDS PYRAZOLE AND DIKETONE METAL COMPLEX AGAINST PATHOGENIC ORGANISMS.

  • Department of Energy Science, Alagappa University, Karaikudi, India.
  • Department of Chemistry, Thiagarajar College, Madurai, India.
  • Department of Botany (DDE), Alagappa University, Karaikudi, India.
  • Department of Microbiology, Alagappa University, Karaikudi, India.
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Schiff base are flexi-dentate ligands, which are important to expand the Schiff base complexes. These complexes form excellent catalytic reaction by forming stable complex with metal ions and producing the biological activity against antibacterial, antifungal, anticancer and anti-malarial activities. In this study, we have explore the Minimum Inhibitory Concentration (both liquid & Disc method) of schiff base ligand such as Pyrazole, diketone and their metal (Ni, Cu, Co, Mn, Vn, Ca, Zn) bound complexes against various microbial pathogens. Minimum Inhibitory Concentration (MIC both liquid & disc method) were analyzed for the various human microbial pathogens such as Pseudomonas aeruginosa, Escherichia coli, Klebsilla pneumonia, Staphylococcus aureus. The sensitivity towards the various commercial antibiotics (Rifampicin, Streptomycin, Ampicillin, Gentamicin, Neomycin, Bacitracin, Erythromycin & penicillin) for the selected microbial human pathogens were also evaluated and compared. The MIC values indicate the most of the complexes have higher antimicrobial activity than the free ligand. The variation in the antimicrobial activity of different metal complexes against different microorganism depends on their impermeability of the cell or the differences in ribosomes in microbial cells. The lipid membrane surrounding the cell favours the passage of any lipid soluble materials and it is known that lipo solubility is an important factor controlling antimicrobial activity. The presence of low activity of some metal complexes is may be due to their low lipophilicity, because of which penetration of the complex through lipid membrane was decrease and neither block nor inhibit the growth of the microorganism.

  1. Andrews, J.M., Andrews, J.M., 2001. Determination of minimum inhibitory concentrations. J. Antimicrob. Chemother. 48 Suppl 1, 5?16. doi:10.1093/jac/48.suppl_1.5
  2. Bhattarai, D., Lee, S.H., Seo, S.H., Nam, G., Kang, S.B., Pae, A.N., Kim, E.E., Oh, T., Cho, S.N., Keum, G., 2012. Synthesis and in vitro antibacterial activity of novel 3-azabicyclo[3.3.0]octanyl oxazolidinones. Chem Biol Drug Des 80, 388?397. doi:10.1111/j.1747-0285.2012.01404.x
  3. Bhava, P.S., Tharmaraj, P., Muthuraj, V., Umadevi, M., 2013. Synthesis , Spectral Characterization , Antimicrobial Screening and DNA Studies of Transition metal complexes of Cu ( II ), Co ( II ), Ni ( ii ) and Zn ( II ) with Heterocyclic Triazol based derivative 3.
  4. Creaven, B.S., Czegl?di, E., Devereux, M., Enyedy, ?.A., Foltyn-Arfa Kia, A., Karcz, D., Kellett, A., McClean, S., Nagy, N.V., Noble, A., Rockenbauer, A., Szab?-Pl?nka, T., Walsh, M., 2010. Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands. Dalton Trans. 39, 10854?10865. doi:10.1039/c0dt00068j
  5. Dickson, I.E., Robson, R., 1974. Complexes of binucleating ligands. VI. Copper(II) complexes of a tetraamine ligand. Inorg. Chem. 13, 1301?1306.
  6. Gibson, B.D., Johnson, B.F.G., Lewis, J., 1970. Some B-Diketone Complexes of Copper(i), Silver(i), and Gold([ 1959?1961.
  7. Lippard, S.J., Berg, J.M., 1995. Principles of Bioinorganic Chemistry, Principles of Bioinorganic Chemistry. doi:10.1016/0307-4412(95)90685-1
  8. Naeimi, H., Safari, J., Heidarnezhad, A., 2007. Synthesis of Schiff base ligands derived from condensation of salicylaldehyde derivatives and synthetic diamine. Dye. Pigment. 73, 251?253. doi:10.1016/j.dyepig.2005.12.009
  9. Nomiya, K., Noguchi, R., Ohsawa, K., Tsuda, K., Oda, M., 2000. Synthesis, crystal structure and antimicrobial activities of two isomeric gold(I) complexes with nitrogen-containing heterocycle and triphenylphosphine ligands, [Au(L)(PPh3)] (HL=pyrazole and imidazole). J. Inorg. Biochem. 78, 363?370. doi:10.1016/S0162-0134(00)00065-9
  10. Pervez, H., Ahmad, M., Zaib, S., Yaqub, M., Naseer, M.M., Iqbal, J., 2016. Synthesis, cytotoxic and urease inhibitory activities of some novel isatin-derived bis-Schiff bases and their copper( <scp>ii</scp> ) complexes. Med. Chem. Commun. 7, 914?923. doi:10.1039/C5MD00529A
  11. Rafi, U.M., Mahendiran, D., Haleel, A.K., Nankar, R.P., Doble, M., Rahiman, A.K., 2016. New pyridazine-based binuclear nickel, copper and zinc complexes as prospective anticancer agents. New J. Chem. 40, 2451?2465. doi:10.1039/C5NJ02739J
  12. Tharmaraj, P., Kodimunthiri, D., Sheela, C.D., Shanmuga Priya, C.S., 2009. Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]hydrazone. J. Serbian Chem. Soc. 74, 927?938. doi:10.2298/JSC0909927T
  13. Yadav, P., Saingar, S., Sharma, A., Joshi, Y.C., 2013. Synthesis and Antibacterial Activity of Some Novel -Diketones / - Ketoesters , from 4-Acetylaminobenzene Sulphonyl Chloride VI, 1?5.

[G. Sivaprakash, P. Tharmaraj, M. Jothibasu and A. Arun. (2017); ANTIMICROBIAL ANALYSIS OF SCHIFF BASE LIGANDS PYRAZOLE AND DIKETONE METAL COMPLEX AGAINST PATHOGENIC ORGANISMS. Int. J. of Adv. Res. 5 (Feb). 2656-2663] (ISSN 2320-5407). www.journalijar.com

A.Arun
Associate professor, Department of Microbiology, Alagappa University, Karaikudi

DOI:

Article DOI: 10.21474/IJAR01/3457      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3457

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