Effect of Streptozotocin- and Alloxan-Induced Hyperglycemia on the First Anagen Cycle in Skin of Mice, Mus musculus

The present investigation was conducted to investigate the effects of both diabetogenic agents streptozotocin- and alloxan-induced hyperglycemia on postnatal skin development of hair follicles at 10th day of delivery during the first anagen cycle. Pups from the same mother were classified and injected from the first day of birth into three groups: control, streptozotocin- and alloxan-treated groups. Pubs were sacrificed at 10th day of birth, the STZ-treated pubs showed elevation in the blood sugar than alloxan-treated pubs as compared to control. The skin of STZ-treated pubs showed several complications, losing of hair coat, bald and wrinkled skin, thickened epidermis and decrease in the content of carbohydrate in the outer root sheath of hair follicles. In addition, the immunohistochemical studies showed the decrease in GDNF, GFR?1, EGF, CTGF and BCL-2 in STZ-treated group as compared to both the control and alloxan-treated pubs. These findings showed that STZ is more effective than alloxan in the induction of skin abnormalities in hyperglycemic model animals. The observed findings were attributed to the inhibition of the growth factors that are essential during hair follicle development in STZ- induced hyperglycemia compared to both the control and alloxan-treated pubs.