27Feb 2017

ANALYSIS OF HYPOLIPIDEMIC EFFECT OF RHINACANTHUS NASUTUS(LINN) KURZ IN HIGH FAT DIET INDUCED HYPERLIPIDEMIC RAT.

  • Professor, Reasearch Supervisor, Sri Venkateswara University, Tirupathi-517503, AP, India.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Objective: To evaluate the hypolipidemic effect of Rhinacanthus nasutus (R.nasutus) in high fat diet induced (HFD) hyperlipidemic rats. Methods: The methanol leaf extract of R.nasutus was tested for hyperlipidemic effect in the albino rats at the selected optimum dosage of 200 mg/kg body weight orally. Adult male albino rats of six numbers in each group were undertaken to study, and evaluated. Results: In group II animals, fed with high fat diet the activity levels of serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein-cholesterol (VLDL) were significantly enhanced when compared to normal rat. Rhinacanthus nasutus methonolic leaf extract (RNM) group III treated rats showed depleted levels of the lipid molecules. Conclusion: It could be concluded that the methanol leaf extract of R.nasutus exhibited a significant hypolipidemic effect on HFD induced hyperlipidemia in rats.

  1. Brai BIC, Odebolt MA, Agoma PU. Effect of Persia Americana leaf extract on body weight and liver lipids in rats fed with hyperlipidemic diet. Afr J Biotechnology 2007; 16(8): 1007-1111.
  2. who.int/media centre/fastsheets/fs317/en. Ref.British Heart foundation(2015) Table.1
  3. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217-223.
  4. Howard-Alpe GM, Sear JW, Foex P. Methods of detecting atherosclerosis in non-cardiac surgical patients; the role of biochemical markers. Br J Anesthesia 2006; 97: 758-769.
  5. Sattivel A, Rao H, Balajiaghavendran. Anti peroxidative and Anti hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactose amine induced hepatitis in rats. Food Chem Toxicol 2000; 46: 3262-3267.
  6. Durrington P. Dyslipidaemia. Lancet 2003; 362: 717-731.
  7. Speight TM. Avery?s drug treatment principles and practice of clinical pharmacology and therapeutics. Australia: Maclennan and Petty; 1987.
  8. Resolution-promotion and development of training and research in traditional medicine. Geneva: WHO; 1977, p. 49-49.
  9. Harborne JB. Photochemical Methods. A Guide to Modern Techniques of Plant Analysis. 1st Edn., London: Chapman and Hall; 1973.
  10. Sofowora A. Medicinal Plant and Traditional Medicine in Africa. 2nd Edn. Ibadan: Spectrum Books; 1996, p. 112.
  11. Kumari K, Augusti KT. Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 2007; 109: 367-371.
  12. Son IS, Kim JH, Sohn HY, Son KH, Kim JS, Kwon CS. Ant oxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea ),on high-cholesterol fed rats.
  13. Indian medical plants. A compendium of 500 species.Chennai:Orient Longman Ltd:1994;4:417
  14. Visweswara rao P, Sivanarayana A,Sasikala S and Dhananjaya M.Efficancy of antimicrobial activity of Rhinachantus Nasutus (Linn) leaves in different exctrations.Int J Pharma Biol Sci.2010 ;(2);1-4
  15. Yesilbursad,Serdar Z,SerdarA,SaracM,Coskun S,JaleC. Lipid peroxides in obese patients and effect of weight loss with Orilistat on lipid peroxides levels. International Journal of Obesity and Related Metabolic Disorder2005;29(1)142e5.
  16. Srinivasan K, Patole PS, Kaul CL, Ramarao P. Reversal of glucose intolerance by pioglitazone in high-fat diet fed rats. Methods Find Exp Clin Pharmacol 2004; 26: 327-333.
  17. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, et al. A new rat model of type 2 diabetes: the fatfed, streptozotocin-treated rat. Metabolism 2000; 49: 1390-1394.
  18. Parekh AC, Jung DM. Cholesterol determination with ferric acetate-uranium acetate and sulphuric acid, ferrous sulphate reagents. Anal Chem 1970; 42: 1423-1427.
  19. Rice LB. Determination of triglycerides (enzymatic method). Clin Chem 1970; 31(5): 746-750.
  20. Lyons TJ. Lipoprotein glycation and its metabolic complications. Diabetes 1992; 41(sup2): 67-73
  21. Chander R, Kapoorn K and Singh C. Lipid per oxidation of hyperlipidemic rat serum in chronic ethanol and acetaldehyde administration. J Biosci 2003; 13: 289-274.
  22. Aparna Berteri R. Risk of coronary artery heart disease. Health Screen 2003; 1: 28-29.
  23. Ma Angeles Zulet, PhD, Ana Barber, PhD, Henri Garcin, PhD, Paul Higueret, PhD, and Jose? Alfredo Martı?nez, PhD, FACN ?Alterations in Carbohydrate and Lipid Metabolism Induced by a Diet Rich in Coconut Oil and Cholesterol in a Rat? Model? Journal of the American College of Nutrition, Vol. 18, No. 1, 36?42 (1999).

[D. Sajeda, K. Jayalakshmi and K. Thyagaraju. (2017); ANALYSIS OF HYPOLIPIDEMIC EFFECT OF RHINACANTHUS NASUTUS(LINN) KURZ IN HIGH FAT DIET INDUCED HYPERLIPIDEMIC RAT. Int. J. of Adv. Res. 5 (Feb). 1841-1846] (ISSN 2320-5407). www.journalijar.com

D.SAJEDA
SRI VENKATESWARA UNIVERSITY

DOI:

Article DOI: 10.21474/IJAR01/3349      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3349

Download Full Paper

Download PDF No. of Downloads: 35 | No. of Views: 141