TIME COURSE OF ALLODYNIA IN THE CHRONIC CONSTRICTION INJURY MODEL OF NEUROPATHIC PAIN.

  • king Faisal university, College of medicine.
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Injury to the peripheral nerves results in chronic neuropathic pain that its mechanism is not well understood. Associated with neuropathic pain is allodynia, painful sensation to non-painful stimuli. Since the mechanism is not fully understood, there is yet no effective treatment for allodynia. The aim of this study is to monitor the time course of tactile allodynia after induced injury to the sciatic nerve. To achieve this aim, 4 Lewis rats were used. Baseline measurements were taken one day before performing chronic constrictive injury (CCI) model of neuropathic pain. Comparing with the contralateral paw, on the first day after CCI, the paw withdrawal threshold of the ipsilateral paw started to decrease, but did not reach the level of significance. The sixth day though, paw withdrawal threshold in ipsilateral was significantly different. Thus, successfully establishing allodynia. On the fifteenth day, measurements of paw withdrawal threshold increased, showing tendency to recovery from CCI. These changes may be related to different immune reactions to nerve injury. Knowing the role of different immune cells and relating them to the time course of allodynia development may give us an idea about the mechanism, and thus, an effective treatment.

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[Asma Alsaeed, Albatoul Almulhim, Fatimah Almajed, Fatimah Majrabi and Karima Kahlat. (2017); TIME COURSE OF ALLODYNIA IN THE CHRONIC CONSTRICTION INJURY MODEL OF NEUROPATHIC PAIN. Int. J. of Adv. Res. 5 (Feb). 2286-2291] (ISSN 2320-5407). www.journalijar.com

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Article DOI: 10.21474/IJAR01/3406      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3406

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