30Mar 2017

LOW SERUM VITAMIN D LEVELS IN EGYPTIAN ADULTS WITH CHRONIC PRIMARY IMMUNE THROMBOCYTOPENIA: A SINGLE CENTER STUDY.

  • Clinical Hematology and Bone Marrow Transplant Unit, Internal medicine department , Faculty of Medicine ? Ain Shams University, Cairo, Egypt.
  • Faculty of medicine- MisurataUniveristy, Misurata, Libya.
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Objectives: Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated accelerated platelet destruction and suppressed platelet production. Low vitamin D levels have been found in several autoimmune diseases, such as rheumatoid arthritis, SLE. The mechanisms underlying the link between vitamin D with autoimmunity are not completely understood. No currently available studies about vitamin D status in primary ITP patients. Aim: To evaluate vitamin D levels in patients with primary chronic ITP and compare these levels with normal control subjects and patients with thrombocytopenia due to other non-immune causes Methods: The study included 80 adult subjects, 40 ITP patients (They were segregated into 20 responders and 20 non-responders), 20 cases of thrombocytopenia due to non ITP causes and 20 healthy control subjects. Measurement of serum 25monohydroxyvitamin D was done with ELISA. Results: Vitamin D levels were significantly lower in patients with ITP (range=2-40ng/ml; mean?SD=17.29?10.96 ng/ml) and thrombocytopenia due to non-ITP causes (range=10-40ng/ml; mean?SD=21.05?8.31 ng/ml) in comparison to normal healthy controls (range = 10-65 ng/ml; mean?SD=36.70?16.30 ng/ml) (P=0.000), but there was no statistically significant difference between levels in ITP versus non- ITP thrombocytopenia (P=0.225).There was no statistical significant difference between responders & non-responders Conclusions: Vitamin D levels are lower among chronic ITP patients in relation to healthy control subjects which might point out to a role in aetiopathogenesis of ITP attributable to vitamin D deficiency.

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[Abdel Rahman A Soliman, M.D, Walaa A Elsalakawy M.D, Alia M Saeed M.D and Sana A Mohammed M.B., B. CH. (2017); LOW SERUM VITAMIN D LEVELS IN EGYPTIAN ADULTS WITH CHRONIC PRIMARY IMMUNE THROMBOCYTOPENIA: A SINGLE CENTER STUDY. Int. J. of Adv. Res. 5 (Mar). 1789-1797] (ISSN 2320-5407). www.journalijar.com

Walaa Ali Elsalakawy
MD

DOI:

Article DOI: 10.21474/IJAR01/3692      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3692

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