30Mar 2017

SCREENING STUDY OF THE RELATIONSHIP BETWEEN TOXOPLASMOSIS AND ABORTION IN HAIL REGION, SAUDI ARABIA.

  • Professor of Pharmacology and Toxicology, Department of Pharmacology, College of Medicine and General Surgery, Hail University, KSA.
  • Lecturer of Microbiology, College of Nursing, Hail University, KSA.
  • Ex-Vice Dean of College of Nursing, Hail University, KSA.
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Toxoplasmosis is one of the most common parasitic infections with variable prevalence in different countries caused by Toxoplasma gondii. The importance of toxoplasma mainly due to the risk of disease transmission during pregnancy and suggested its role in abortion. Chronic toxoplasmosis causes repeated abortion especially at first trimester. Objective: This study aims to determine the proportion of women with Toxoplasmosis who experienced recurrent abortion among 2 years 1432 and 1433 and the relationship between the incidence of Toxoplasmosis and recurrent abortion in Hail with the effect of treatment. Subjects and method: Data was collected from Maternity and Children's Hospital in Hail as a representative case in Hail, Saudi Arabia about women who had suffered from recurrent abortion (3 or more) among 2 years 1432 and 1433 and the seroprevalence of Toxoplasma gondii antibodies in pregnant women. Results: indicate that the percentage of abortion due to toxoplasmosis in relation to total abortion due to different causes among 2 years (1432 & 1433) was found to be 2.85%. High percentage was found at first trimester (62.1%) followed by second trimester (31%) and then third trimester (6.9%). There is no significant difference between percentages either in year 1432 or 1433. High percentage of abortion due to Toxoplasma gondii was found in participant women with age of 25-45 years old. Conclusion: We can conclude that it is of great importance to avoid raw or undercooked meat, preventing close contact with cats and early treatment from toxoplasmosis.


  1. Al-Harthi, S.A, Jamjoom, M.B., Hani, O. (2006): Seroprevalence of Toxoplasma Gondii Among Pregnant Women in Makkah, Saudi Arabia. Ghazi Umm Al-Qura Univ. J. Sci. Med. Eng; 18: 217 -227.
  2. Al-Hindi, A.I., Lubbad, A.M.H. (2009): Seroprevalence of toxoplasmosis among Palestinian aborted women in Gaza. Annals of Alquds medicine, 5: 39-47.
  3. Al-Mohammad, H.I., Amin,T.T., Balaha, M.H., et al. (2010): Toxoplasmosis among the pregnant women attending a Saudi maternity hospitals: Seroprevalence and possible risk factors. Ann HYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/20863438\"TropHYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/20863438\" Med HYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/20863438\"Parasitol 104 (6):493-504.
  4. Ashraf, , Al-Nahari, Abdul-Haleem, S., Al-Tamimi (2010): Seroprevalence of Anti Toxoplasma gondii IgG and IgM Among Pregnant Women in Sana?a Capital. Sci. J. King Faisal Uni. (Basic and applied Sciences)., 11 (2): 179-188.
  5. I., Sowah, A.O., Blay, E.A., Akashi?Suzuki, T., Ohta, N., Ayeh-Kumi, P.F. (2016): Toxoplasma gondii?infections among pregnant women, children and HIV-seropositive persons in Accra, Ghana. Trop. Med. and Health, 44:17. DOI:?10.1186/s41182-016-0018-5
  6. Caroline Paquet, R.M., Trois-Rivi?res, Q.C., Mark, H., Yudin, M.D., Toronto, O.N. (2013): ?Toxoplasmosis in Pregnancy: Prevention, Screening, and Treatment, J Obstet Gynaecol Can., 35 (1 A):S1?S7.
  1. Chessa, G., Chisu. V., Porcu, R., et al. (2014): Molecular characterization of Toxoplasma gondii Type II in sheep abortion in Sardinia, Italy. Parasite, 21:6.
  2. De Paschale, M., Agrappi, C., Clerici, P., et al. (2006): Prevalence of?Toxoplasma gondii?infection in the Italian and foreign female population living in the area of Legnano (Milan)?Microbiol Med, 21:322?327.
  3. Ebadi, P., Solhjoo, K., Bagheri, K., et al. (2011): Seroprevalence of toxoplasmosis among the women with recurrent spontaneous abortion in comparison with the women with uncomplicated delivery. Jahrom Uni. . Med. Sci, 9(1): 33-37.
  4. Elmore, S.A., Jones, J.L., Conrad, P.A., Patton, S., Lindsay, D.S., Dubey, J.P. (2010): Toxoplasma gondii: epidemiology, feline clinical aspects, and prevention. Trends Parasitol., 26 (4): 190?6.
  5. El-Sebai, M.M.(1991): Study on toxoplasmosis in Quasseem, Saudi Arabia. J Egypt Soc HYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/2033301\"Parasitol., 21(1): 273-5.
  6. Elsheikha, H.M. (2008): Congenital toxoplasmosis: priorities for further health promotion action. Public Health, 122(4): 335-353.
  7. Ertug, S., Okyay, P., Turkmen, M., et al. (2005): Seroprevalence and risk factors for toxoplasma infection among pregnant women in Aydin province, Turkey. BMC Public Health,15(5): 66.
  8. Foulon, W., Villena, I., Pedersen, B., et al. (1999): Treatment of toxoplasmosis during pregnancy: A multicenter study of impact on fetal transmission and children?s sequelae at age 1 year. American Journal of Obstetrics & Gynecology, 180(2): 410-415.
  9. Galvan-Ramirez, M. , de la L., Soto Mancilla J.L., Velasco Castrejon O., et al. (1995): Incidence of anti-Toxoplasma antibodies in women with high risk pregnancy and habitual abortion. Rev Soc Bras Med Trop., 28(4): 333-37.
  10. Ghasemi, F.S.,?Rasti, S.,?Piroozmand, A.,?et al. (2016): Toxoplasmosis-associated abortion and stillbirth in Tehran, Iran. J Matern Fetal Neonatal Med., 29(2): 248-51.
  11. Han, S.Y., Yoon, T.K., Cha, K.Y., et al. (1999): A Case of Toxoplasmosis Detected in Habitual Aborter. ?Korean J HYPERLINK \"http://www.koreamed.org/SearchBasic.php?QY=%22Korean+J+Obstet+Gynecol%22+%5BJTI%5D&DisplaySearchResult=1\"ObstetHYPERLINK \"http://www.koreamed.org/SearchBasic.php?QY=%22Korean+J+Obstet+Gynecol%22+%5BJTI%5D&DisplaySearchResult=1\" HYPERLINK \"http://www.koreamed.org/SearchBasic.php?QY=%22Korean+J+Obstet+Gynecol%22+%5BJTI%5D&DisplaySearchResult=1\"Gynecol., 42(2): 436-438.
  12. Hohlfeld, P., Daffos, F., Thulleiz, P., et al. (1989): Fetal toxoplasmosis: Outcome of pregnancy and infant follow-up after in utero treatment. The Journal of Pediatrics, 115(5): 765?769.
  13. Leproust, S., Chene, G., Gilbert, R. (2007): Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients\' data. Lancet, 369 (9556): 115-122 .
  14. Minbaeva, G.,?Schweiger, A.,?Bodosheva, A.,?Kuttubaev, O., et al. (2013): Toxoplasma gondii infection in Kyrgyzstan: seroprevalence, risk factor analysis, and estimate of congenital and AIDS-related toxoplasmosis.PLoS Negl Trop Dis., 7(2):e2043. doi: 10.1371/journal.pntd.0002043.
  15. Murata, F.H.A.; Ferreira, M.N, Camargo, N.S.; Santos, G.S.; Spegiorin, L.C.J.F.; Silveira-Carvalho, A.P.; Pereira-Chioccola,V.L.; de?Mattos, L.C.; de?Mattos, C.C.B.?(2016): Frequency of anti-?Toxoplasma gondii?IgA, IgM, and IgG antibodies in high-risk pregnancies, in Brazil.; Rev Soc Bras Med Trop 49(4): 512-514.
  1. Mwambe, B.,?Mshana, S.E.,?Kidenya, B.R.,?et al. (2013): Sero-prevalence and factors associated with Toxoplasma gondii infection among pregnant women attending antenatal care in Mwanza, Tanzania. Parasit Vectors, 6:222.
  2. Nijem, K.I.,?Al-Amleh, S. (2009): Seroprevalence and associated risk factors of toxoplasmosis in pregnant women in Hebron district, Palestine. East Mediterr Health J., (5):1278-84.
  3. Nogareda, F., Le Strat, Y., Villena, I., De Valk, H., Goulet, V. (2014): Incidence and prevalence of?Toxoplasma gondiiinfection in women in France, 1980?2020: model-based estimation.?Epidemiol. Infect.?142: 1661?1670.
  4. Pomares, C., Montoya, J.G. (2016): Laboratory diagnosis of congenital toxoplasmosis. J Clin Microbiol., 00487-16.
  1. Qublan, H.S., Jumaian, N., Abu-Salem, A., et al.. (2002):Toxoplasmosis and habitual abortion. Obstetrics & Gynaecology, 22(3): 296-298.
  2. Remington, J.S., Mcleod, R., Thulliez, P..Toxoplasmosis. In: Remington JS, Klein JO, Baker C, et al (eds). Infectious disease of the fetus and newborn infant. Philadelphia: W. B. Saunders; 2006: 947-1092.
  3. Rodrigues, I.M., Costa, T.L., Avelar, J.B., Amaral, W.N., Castro, A.M., Avelino, M.M. (2014): Assessment of laboratory methods used in the diagnosis of congenital toxoplasmosis after maternal treatment with spiramycin in pregnancy. BMC Infect Dis., 14: 349.
  1. Sahwi, S., Zaki, M., Haiba, N., et al. (1995): Toxoplasmosis as a Cause of Repeated Abortion. Obstetrics & Gynaecology Research, 21(2): 145-148.
  2. Saki, J., Mohammadpour, N., Moramezi, F., et al. (2015): Seroprevalence of?Toxoplasma gondii?in Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran. The Scientific World Journal:doi:10.1155/2015/764369: 4 pages.
  3. Sakikawa, M.,?Noda, S.,?Hanaoka, M.,?et al. (2011): Anti-Toxoplasma antibody prevalence, primary infection rate, and risk factors in a study of toxoplasmosis in 4,466 pregnant women in Japan, 19(3): 365-367.
  4. Skariah, S., McIntyre, M.K., Mordue, D.G. (2011): Toxoplasma gondii: determinants of tachyzoite to bradyzoite conversion. Parasitol Res, 107(2): 253?60.
  5. Stray-Pedersen, B. (1992): Treatment of toxoplasmosis in the pregnant mother and newborn child. Scand J Infect HYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/1290070\"DisHYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/1290070\" HYPERLINK \"http://www.ncbi.nlm.nih.gov/pubmed/1290070\"Suppl., 84: 23-31.
  6. Vado-Sol?s, I.A., Su?rez-Sol?sm, V.M., Jim?nez-Delgadillo, B., et al. (2013): Toxoplasma gondii?presence in women with spontaneous abortion in Yucatan, Mexico.?J Parasitol., 99: 383?385.
  7. Zargar, A.H., Masoodi, S.R., Laway, B.A., et al. (1998): Seroprevalence of toxoplasmosis in women with repeated abortions in Kashmir. J Epidemiol Community Health, 52(2): 135-6.
  8. Zargar, A.L., Wani, A.L., Masoodi, S.R., et al. (1999): Seroprevalence of toxoplasmosis in women with recurrent abortions/neonatal deaths and its treatment outcome. Indian Pathol Microbiol., 42(4): 483-6.

[Madiha Rabie Mahmoud, Ghadeer Mohammed Rasheed Swais and Somaya Abdull-Mohsen Almashari. (2017); SCREENING STUDY OF THE RELATIONSHIP BETWEEN TOXOPLASMOSIS AND ABORTION IN HAIL REGION, SAUDI ARABIA. Int. J. of Adv. Res. 5 (Mar). 2358-2366] (ISSN 2320-5407). www.journalijar.com


Madiha Rabie Mahmoud
Department of Pharmacology, College of Medicine and general surgery, Hail University, KSA.

DOI:


Article DOI: 10.21474/IJAR01/3765      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3765