CDCP1, A NOVEL CUTANEOUS MARKER, EXPRESSION IN PSORIASIS VULGARIS.

Background: Psoriasis is a common inflammatory skin disease, CDCP1 is a cell-surface integral glycoprotein. This study assesses the presence and distribution of CDCP1 in psoriasis vulgaris. Materials and Methods:Thirty paraffin blocks from lesions of patients with psoriasis and twenty paraffin blocks as a control group were collected. Histopathological grading was performed for all cases.Immunohistochemical staining and image analysis was performed to detect CDCP1 expression. Results: our cases ranged from 9 to 18 out of 19 total points of the used grading system. The intensity immunostaining of CDCP1 in all biopsies of the control group (n=20) was low (+1), while in cases group (n=30) was moderate (+2) in 8 cases (26.7%) and high (+3) in 22 cases (73.3%).There were a significant difference(P value <0.001) between cases and control group regarding to immunostaining of CDCP1, and a significant positive relation (P value < 0.001) between the histological grading score and immunostaining of CDCP1 and positive relation (p=0.002) between the duration of disease and the immunostaining ofCDCP1. Conclusion: CDCP1 was overexpressed by keratinocytes in lesional psoriasis compared with non-lesionalskin and normal skin which points to a possible role of CDCP1 in the pathogenesis of psoriasis.