25Apr 2017

CORRELATION OF ANTI-THYROID PEROXIDASE ANTIBODIES (ANTI-TPO) WITH THYROID HORMONES IN LOCAL POPULATION OF WESTERN NEPAL.

  • Department of Medicine, Western regional Hospital. Pokhara, Nepal.
  • Gandaki Medical College and Teaching Hospital Pvt. Ltd. Pokhara, Nepal.
  • Charak Academy, Pokhara, Nepal.
  • College of Applied Medical Sciences, Al Jouf University, Al Qurayyat, Saudi Arabia.
  • Department of Biochemistry, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
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Background: Thyroid disorders are more common in Nepalese population. Thyroid autoimmunity can cause several forms of thyroid disorders ranging from hypothyroidism to hyperthyroidism. Anti-TPO Ab has emerged as the most generally useful marker for the diagnosis and management of autoimmune thyroid disease. Objective: This study was undertaken to investigate the association between Anti-TPO antibody and thyroid dysfunction in population of western Nepal Material and Methods: A hospital-based cross-sectional study involving 100 patients was conducted in the Department of Medicine, Gandaki Medical College and Teaching Hospital Pvt. Ltd. Pokhara, Nepal, Nepal during December 2015 to June 2016. Patient?s data collection and relevant laboratory test [serum fT3, fT4, TSH and Anti TPO] were performed in the Department of Laboratory, Gandaki Medical College and Teaching Hospital. Thyroid abnormalities were diagnosed on the basis of these laboratory results. All the parameters were measured using CLIA method (DiaSorin Liaison @R Instrument). Results: The prevalence of the abnormal anti-TPO antibody is 25.93% in male and 74.07% in female group was noticed. The anti-TPO prevalence was higher in females than in males. In addition, Anti-TPO antibody has statistical significant correlation with TSH and fT4 but not with fT3. Conclusion: In conclusion, our study demonstrates that in autoimmune thyroiditis is more common in Nepalese females then men. This confirms the correlation between thyroid hormones and Anti-TPO antibody.

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[Sachin Dhakal, Amar Nagila, Reetu Koirala, Mahendra Prasad Bhatta, Sanjib Mani Regmi, Alneil M. Hamza and Dipendra Raj Pandeya. (2017); CORRELATION OF ANTI-THYROID PEROXIDASE ANTIBODIES (ANTI-TPO) WITH THYROID HORMONES IN LOCAL POPULATION OF WESTERN NEPAL. Int. J. of Adv. Res. 5 (Apr). 692-699] (ISSN 2320-5407). www.journalijar.com

Dipendra
Al Jouf University

DOI:

Article DOI: 10.21474/IJAR01/3865      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3865

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