SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SOME PHTHALAZIN-1(2H)-ONE URANYL NITRATE COMPLEX ANTICANCER.

  • Department of Organic Chemistry , Faculty of Science, University of Ain Shams ,Cairo, Egypt.
  • Department of reactor materials , nuclear material authority Egypt, Egypt
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A new series of phthalazin-1(2H)-one complex and studying of the spectroscopic like FT-IR , 1H-NMR and HEPG-2 properties as application of complex The biological activity as antitumor. compound has an significant anticancer activity against human liver carcinoma cells HEPG-2 to the ligand and the determine the urinal nitrate complex Uo2(4-(3-chloro-4-methylphenyl)-1-oxophthalazin-2(1H)-yl)acetate)2. (NO3)26.H2O 5 are showing high cytotoxicity 48ug/ml than the ligand 4-(3-chloro-4-methylphenyl)-1-oxophthalazin-2(1H)-yl)acetate) as antitumor against a panel of human tumour cell lines HEPG-2 comparing with the other complex have urinal nitrate don?t have any biological activity against human liver carcinoma .

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[M. A. EL-Hashash, S. A. Rizk, F.A. El-Bassiouny, D. B. Guirguis, L.A. Guirguis and S. M. Khairy (2017); SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF SOME PHTHALAZIN-1(2H)-ONE URANYL NITRATE COMPLEX ANTICANCER. Int. J. of Adv. Res. 5 (Apr). 1343-1349] (ISSN 2320-5407). www.journalijar.com

sameh rizk
chemistry department, faculty of science ain shams university

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Article DOI: 10.21474/IJAR01/3956      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3956

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