30Apr 2017

STABLE DRUG DELIVERY SYSTEMS: PEG-POLYDIACETYLENE LIPOSOMES.

  • Process chemistry DR.V.Swapna ,National Institute of Pharmacutical science and research ,Hyderabad, India.
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In a new preliminary approach we esterified the PDA (10, 12-pentacosadiynoic acid) with oligoethyleneoxides (PEG-PDA) to prepare non-ionic tensides with polymerizable diacetylene entities. The synthetic approach coupled the activated carboxygroups of PDA to amino terminated oligoethyleneoxides. Conjugation of Polyethylene glycol to diacetylene entities enhances the stability of the liposomes. Due to their unique properties such as high water-solubility, cross-linkable micelle formation with a nano-scaled size, and stimuli-responsive chromic nature, the polymer-lipid conjugates would be useful for various biomedical applications, in particular drug delivery system and biosensors.

  1. Chance, R. R. Macromolecules 1980, 13, 396.
  2. Chance, R. R.; Patel, G. N.; Witt, J. D. J. Chem. Phys. 1979, 71, 206.
  3. Charych, D. H. Am. Chem. Soc. 1999, 121, 4580.
  4. Charych, D. H.; Cheng, Q.; Reichert, A.; Kuziemko, G.; Stroh, M J. O. Nagy, W. Spevak and Stevens, Biol., 1996, 3, 113-120.
  5. Charych, D. H.; Nagy, J. O.; Spevak, W.; Bednarski, M. D. Science 1993,261, 585.
  6. Cheng, Q.; Stevens, R. C. Langmuir 1998, 14, 1974.
  7. Cheng, Q.; Stevens, R. C. Langmuir 1998, 14, 1974.
  8. Meyer , Hans George Braun, Langmuir (submited) 2000 .
  9. Forssen, E. A.; Male-Brune, R.; Adler-Moore, J. P.; Lee, M. J.; Schmidt,P. G.; Krasieva, T. B.; Shimizu, S.; Tromberg, B. J. Cancer Res. 1996, 56, 2066.
  10. Gabizon, A.; Papahadjopoulos, D. Proc. Natl. Acad. Sci. U.S.A. 1988, 85, 6949.
  11. Graham NB, McNeil ME 1984 Biomaterials 5:27.
  12. Guo, C. X.; Boullanger, P.; Liu, T.; Jiang, L. J. Phys. Chem. B 2005, 109, 18765.
  13. Harris JM, Poly(ethy1ene glycol) Chemistry. Biotechnical and Biomedical Applications, 1992 Plenum Press, New York.
  14. Harris JM, Zalipsky S Poly(ethy1ene glycol) Chemistry and Biological Applications; ACS Symposium Series: American Chemical Society: Washington, 1997 DC, No. 680.
  15. Hub, H.-H.; Hupfer, B.; Koch, H.; Ringsdorf, H. Chem., Int. Ed. Engl. 1980, 19, 938-940.
  16. Hye Choi and Joon Sig Choi.; Bull. Korean Chem. Soc. 2013, Vol. 34, No. 10 3083.
  17. D.Hood, M.Bednarski, R.Frausto, S.Guccione, R.A.Reisfeld,R.Xiang, and .A.Cheresh, Science 296, 2404 (2002).
  18. Jelinek, R. Kolusheva, S.; Kafri, R.; Katz, M.; Am. Chem. Soc. 2001.
  19. Kim, J.-M.; Ji, E.-K.; Woo, S.-M.; Lee, H.; Ahn, D. J. AdV. Mater. 2003, 15, 1118.
  20. Kolusheva, S., Kafri, R., Katz, M., Jelinek, R., 2001. Rapid colorimetric detection of antibody-epitope recognition at a biomimetic membrane interface. J. Am. Chem. Soc. 123, 417?422.
  21. Lindsell, W.E., Murray, C., Preston, P.N., Woodman, T.A.J., Synthesis of 1,3-diynes in the purine, pyrimidine, 1,3,5-triazine and acridine series. Tetrahedron 56 (9), 1233?1245.
  22. Mayer, L. D.; Masin, D.; Nayar, R.; Boman, N. L.; Bally, M. B. Br. J. Cancer 1995, 71, 482.
  23. Mayer, L. D.; Tai, L. C.; Ko, D. S.; Masin, D.; Ginsberg, R. S.; Cullis, P. R.; Bally, M. B. Cancer Res. 1989, 49, 5922.
  24. Nagy, J. O.; Spevak, W.; Stevens, R. C. Biol. 1996, 3, 113.
  25. Nallicheri, R. A.; Rubner, M. F. Macromolecules 1991, 24, 517.
  26. O?Brien, D.; Whitesides, T.; Klingbiel, R. Polym. Sci., Polym. Lett. Ed. 1981, 19, 95.
  27. Reichert, A., Nagy, J.O., Spevak, W., Charych, D., 1995. Polydiacetylene liposomes functionalized with sialic acid bind and colorimetrically detect influenza virus. J. Am. Chem. Soc. 117 (28), 7301?7306.
  28. K olusheva, L.Bo yer, and R.Jelinek, Nat. Biotechnol. 18, 225 (2000).
  29. Okada, S.Peng, W.Spe vak, and D.Charych, Acc. Chem. Res. 31,229 (1998).
  30. Trester-Zedlitz, M., Kamada, K., Burley, S.K., Fenyo, D., Chait, B.T. ,Muir, T.W., 2003. A modular cross-linking approach for exploring protein interactions. J. Am. Chem. Soc. 125 (9), 2416?2425.
  31. Zhang, C.Zhu, and W.M.P ardridge, Mol. Ther. 6, 67(2002).
  32. Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K 1991 Cancer Res 5 1 :3229.
  33. Yu, G. S.; Choi, H.; Bae, Y. M.; Kim, J.; Kim, J. M.; Choi, J. S. J. Nanosci.Nanotechnol. 2008, 8, 1.
ZHANG, D. Q.;? XUE? W. X.;? ZHANG G. X.;? ZHU? D. B.; 201

[V. Swapna. (2017); STABLE DRUG DELIVERY SYSTEMS: PEG-POLYDIACETYLENE LIPOSOMES. Int. J. of Adv. Res. 5 (Apr). 1811-1815] (ISSN 2320-5407). www.journalijar.com

Swapna
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DOI:

Article DOI: 10.21474/IJAR01/4017      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4017

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