HEART-TYPE FATTY ACID-BINDING PROTEIN (H-FABP) IS A MORE ACCURATE BIOMARKER FOR EARLY DIAGNOSIS OF PATIENTS WITH ACUTE CORONARY SYNDROME.

  • Clinical Pathology Department, Faculty of Medicine, Zagazig University and Pathology Department College of Medicine, King Khalid University.
  • Cardiology Department, Faculty of Medicine, Zagazig University, Egypt.
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Background: Old biochemical markers were used as acute myocardial infarction (AMI) indicators such as serum Aspartate Transaminase (AST) and Lactic Dehydrogenase-1 (LDH-1), Myoglobin (MYO), Creatine Kinase-MB (CK-MB), Troponin T and I (cTn-T, cTn-I). Later, other cardiac biomarkers such as H-FABP can be detected in the blood within one to three hours of the pain. Aim of the work: To determine the efficacy of H-FABP compared with cTn-T as an early biomarker in the acute coronary syndrome with ST segment elevation myocardial infarction (ACS-STEMI) in patients presenting with acute cardiac chest pain. Patients and methods: This work was carried out on 75 patients fulfilled the inclusion criteria and 25 subjects matched for age and risk factors were included as a control group. All of the patients and controls were subjected to routine clinical, laboratory investigations and assay of cardiac enzymes (cTn-T and h-FABP). Results: This study showed that H-FABP was a sensitive and specific marker for the early detection of AMI, especially within 3h after the onset of chest pain (92.86% and 90.0% versus 81.8% and 88.2% for Troponin), with high diagnostic accuracy for AMI in 0-3 h from onset of chest pain than Troponin (92.45 versus 85.7 for Troponin). Conclusion: H-FABP was an early marker of ischemia; that was detected before any detectable change in (cTn-T) even in the absence of myocardial necrosis.

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Mohamed Eissa, Ekhlas Hussein, Zizi Saad and Mohammad Elrawy. (2017); HEART-TYPE FATTY ACID-BINDING PROTEIN (H-FABP) IS A MORE ACCURATE BIOMARKER FOR EARLY DIAGNOSIS OF PATIENTS WITH ACUTE CORONARY SYNDROME., Int. J. of Adv. Res., 5 (04), 1832-1846, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/4021

Mohamed Eissa
Clinical Pathology Department, Faculty of Medicine, Zagazig University and Pathology Department College of Medicine, King Khalid University

DOI:

Article DOI: 10.21474/IJAR01/4021      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4021

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