20May 2017

PROTEIN KINASE C ZETA INHIBITORS: A NEW HOPE FOR CONTROLLING MATERNAL INTRAUTERINE INFECTION INDUCED PREMATURE BIRTH.

  • M.Sc. Biotechnology, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT)-Bombay, Mumbai, India
  • Scientist C, Division of Molecular Oncology, National Institute of Cancer Prevention and Research (NICPR), ICMR, Noida, India.
  • ICMR-Post Doctoral Fellow, National Institute of Cancer Prevention and Research (NICPR), ICMR, Noida, India.
  • Associate Professor, Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, USA.
  • Director of clinical laboratories and Associate professor of obstetrics and gynecology, Oklahoma State University Center for Health Sciences, USA.
  • M.Sc. Medical Microbiology, M.M. Institute of Medical Science and Research, Ambala, Haryana, India.
  • Associate Professor, Department of Microbiology, Swami Shraddhanand College, University of Delhi, Delhi India.
  • Assistant Professor, Department of Microbiology, M.M. Institute of Medical Science and Research, Ambala, Haryana, India.
  • Professor and Head of the Department, Department of Microbiology, Glocal Medical College, Saharanpur, UP, India.
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Premature birth is one of the leading causes of newborn death, estimated 1 in 10 newborn babies. The maternal intrauterine tract infections account for 30-40% of total premature birth. The maternal intrauterine infections are treated with antibiotics, but the neonatal mortality rate has not been decreased. The tocolytic drugs only delay premature delivery for at least 48 hours, but also cause side effects to both mother and the newborn. The protein kinase C (PKC) isoform known as PKC zeta (PKCZ) plays an important role in premature birth. The reports suggest that PKCZ inhibitors have a great potential for being developed as a new drug target for preventing premature birth.

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[Arun Kumar, Showket Hussain, Ankita Singh, Rashmi Kaul, Anil Kaul, Rahul Prabhas, Sunil Kumar Srivastava, Nitin Goel and V. K. Narang. (2017); PROTEIN KINASE C ZETA INHIBITORS: A NEW HOPE FOR CONTROLLING MATERNAL INTRAUTERINE INFECTION INDUCED PREMATURE BIRTH. Int. J. of Adv. Res. 5 (May). 465-474] (ISSN 2320-5407). www.journalijar.com

Arun Kumar
M.Sc. Biotechnology

DOI:

Article DOI: 10.21474/IJAR01/4132      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4132

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