28May 2017

ANTIVIRAL ACTIVITY OF SECONDARY METABOLITES PRODUCED BY STREPTOMYCES SPECIES ISOLATED FROM EGYPTIAN SOIL.

  • In process control manager of diphtheria and tetanus plant, the holding company for the production of vaccines, sera and drugs (vacsera).
  • Professor of microbiology and immunology, faculty of pharmacy, British university, Egypt.
  • Head of R & D sector, the holding company for the production of vaccines, sera and drugs(vacsera).
  • Lecturer of microbiology and immunology, faculty of pharmacy Cairouniversity, Egypt.
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Virus infections pose significant global health challenges, due to the emergence of resistant viruses. Therefore, it is imperative that safe and conventional antiviral drugs be developed. In the present study, Actinomycetes isolated form Egyptian soil samples were used to investigate the possibility of acquiring antiviral activity from their metabolites by testing against three selected virus models. Results revealed that the sixth fraction purified from isolate (H47/60) metabolites induced significant reduction of virus infectivity titer recording 4.13 ? 0.181log (10) / ml, 2.79 ? 0.110 log (10)/ ml and 3.38? 0.185 log (10)/ ml for HAV, HSV-2 and VSV respectively. Further evaluation of the antiviral activity of the metabolite against three types of viruses was attempted by conjugation to silver nanoparticles.

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[Heba Ali Abd El Gaied, Abd El Gawad Mohammed Hashem, Aly Mohamed Fahmy and Marwa Tarek El-Rakaiby. (2017); ANTIVIRAL ACTIVITY OF SECONDARY METABOLITES PRODUCED BY STREPTOMYCES SPECIES ISOLATED FROM EGYPTIAN SOIL. Int. J. of Adv. Res. 5 (May). 1165-1174] (ISSN 2320-5407). www.journalijar.com

Heba Ali Abd el gaied
THE HOLDING COMPANY FOR THE PRODUCTION OF VACCINES, SERA AND DRUGS (VACSERA)

DOI:

Article DOI: 10.21474/IJAR01/4227      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4227

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