The Relationship of Adiponectin/Leptin Ratio with Insulin Resistance and obesity in north Indian population

Adiponectin and leptin both react in a reciprocal approach with increasing obesity, leptin increases while adiponectin decreases with the obesity. Therefore, in the present study we investigate the relationships of A/L ratio with insulin resistance measured by HOMA-IR. This study was a population-based cross-sectional study, only 642 (BMI 29.14±2.54 kg/m2) individual were participated. Commercial kits were used for determining lipid profile. Insulin, leptin were determined by enzyme-linked immunosorbent assay. Adiponectin was assayed with ELISA method. Spearman’s correlation, multiple regression and one-way analysis of variance (ANOVA) were conducted. Mean leptin and Homeostasis model assessment-insulin resistance (HOMA-IR) levels were significantly higher, while Adiponectin /Leptin ratio (A/L ratio) and adiponectin were significantly lower in obese subjects in comparison to overweight and lean subjects. In multiple regression analysis, HOMA-IR was significantly correlated with fasting glucose, insulin and A/L ratio, while A/L ratio were significantly correlated with weight, body mass index, percent body fat, leptin, adiponectin and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors. The decreased A/L ratio in obese subjects, suggests its property as the predictive marker for insulin resistance in the north Indian population.