Impact of Chronic Dose of Dioxin (TCDD) on Haematological and Biochemical Parameters in Mice, Musmusculus L.

Persistent organic pollutants (POPs) are compounds that have been detected as contaminants in almost every component of the global ecosystem including the air, water, sediments, fish, wildlife human adipose tissue, milk, and serum. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) belongs to the group of persistent organic pollutants (POPs), and is reported to be an extremely potent toxin. The current study was designed to investigate the effects on physical, haematological and biochemical parameters due to oral administration of chronic low dose (0.00005 µg/Kg body wt.) of TCDD at the intervals of 4, 8, 12 and 16 weeks in Swiss albino mice. Results indicated marked physical changes as well as statistically very significant (p<0.01) decreased levels of RBC, HCT, Hb, MCV, MCH, MCHC, and WBC after all the experimental duration in TCDD treated mice. The levels of ALT, ALP, total protein, albumin, urea, and creatinine increased in time dependent manner and were statistically very significant (p<0.01). Hence, epidemiological studies expecting similar effects from low-dose exposure to TCDD may produce a series of haematological and biochemical changes in the body.