28Jul 2017

OXIDATIVE STRESS, ANTIOXIDANT SCAVENGING SYSTEMS AND DIABETES MELLITUS: A CONCISE REVIEW.

  • Department of Biochemistry, Jinnah University for Women, Karachi ? Pakistan.
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The enormous majority of complex life on earth requires oxygen for its survival. Oxygen is an extremely reactive molecule that damages living organisms by producing reactive oxygen species leading to oxidative stress. Oxidative stress arrived from increasing amount of ROS or as a consequence of increased levels of lipid peroxides and free-radical intermediates, as well as the reduced total antioxidant capacity that may cause the reduction of molecular oxygen or oxidation of water to leads to the formation of free radicals that could damage cellular lipids, membranes, proteins and DNA (Rains et al, 2011). Living organisms have a complex network of antioxidant metabolites and enzymes that work mutually to prevent oxidative damage to cellular components Ido et al, 1997). Advanced oxidative stress and alterations in antioxidant potential, observed in both clinical and investigational diabetes mellitus. Alteration in oxidative stress biomarkers, including Catalase, superoxide dismutase, glutathione, glutathione reductase, glutathione peroxidase, antioxidant vitamins, lipid peroxidation, non enzymatic glycosylated proteins, are helpful in identifying the risk of developing vascular complications in diabetics.

  1. Agarwal S, Banerjee S, Chatterjee SN.(1985): Effects of oxygen on ferrous sulphate induced lipid peroxidation in liposomal membrane. Indian J Biochem Biophys; 22(6): 331-334.
  2. Atkinson; Epand, RF; Epand, RM .(2008):Tocopherols and tocotrienols in membranes: A critical review. Free radical Biol Med.; 44 (5): 739?764.
  3. Barondeau DP, Kassmann CJ, Bruns CK, Tainer JA, Getzoff ED.( 2004): Nickel superoxide dismutase structure and mechanism. Biochemistry.; 43(25): 8038-8047.
  4. Baynes JW, Thorpe SR.(1999): Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes.; 48: 1-9.
  5. Baynes JW.(1991): Role of oxidative stress in development of complications in diabetes. Diabetes; 40: 405-412.
  6. Bierhaus A, Hofmann MA, Ziegler R., Nawroth PP.(1998): AGEs and their interaction with AGE- receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovasc. Res.; 37: 586?600.
  7. Borgstahl GE, Parge HE, Hickey MJ, Beyer WF Jr, Hallewell RA, Tainer JA.(1992): The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. Cell.; 71: 107?118.
  8. Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, (2001) :Scavenger receptors, oxidized LDL and atherosclerosis. Ann. N.Y. Acad. Sci.; 947:214?222.
  9. Brownlee M, Cerami A, Vlassara H.( 1998): Advanced glycosylation end product in tissue and the biochemical basis of diabetic complications. N Engl J Med.; 318: 1315-1321.
  10. Bruce-Keller AJ, Li YJ, Lovell MA, Kraemer PJ, Gary DS, Brown RR, Markesbery WR, Mattson MP.( 1998) 1998: 4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visiospatial memory in rats. J NeuropatholExp Neurol.; 57: 257 ?267.
  11. Campana F, Zervoudis S, Perdereau B, Gez E, Fourquet A, Badiu C, Tsakiris G, Koulaloglou S. (2004): Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis. J Cell Mol Med.; 8 (1): 109?116.
 
  1. Ceriello A. (2000): Oxidative stress and glycemic regulation, Metabolism.; 49(2): 27?29.
  2. Chattergee SN, Agrawal S, Amit K. (1988): Membrane lipid peroxidation and its pathological consequence. Ind. J. of Biochem and Biophys.; 25: 31.
  3. Chelikani P, Fita I and Loewen PC. (2004): Diversity of structures and properties among catalases. CMLS, Cell. Mol. Life Sci.; 61: 192 ? 208.
  4. Davi G, Falco A, Patrono C. (2005): Lipid peroxidation in diabetes mellitus. Antioxid. Redox Signal.; 7: 256-268.
  5. Dawson J and Walters M. (2006): Uric acid and xanthine oxidase: Future therapeutic targets in the prevention of cardiovascular disease? Br J Clin Pharmacol.; 62(6): 633?644.
  6. DCCT Research Group. (1993): The effect of intensive treatment of diabetes on the development and progression of long-term complications in Insulin-Dependent Diabetes Mellitus. N EnglJ ; 329: 977-986.
  7. Etsuo N, Yasukazu Y, Saito Y, Noguchi N. (2005): Lipid peroxidation: Mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun.; 338: 668?676.
  8. Evans JL. Goldfine ID. Maddux BA. Grodsky GM. (2002): Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr Rev.; 23:599?622.
  9. Farah Jabeen, Asher Fawwad, Husan Afroz Rizvi, Faraz Alvi, Farha Aziz. (2014) :Evaluation of Lipid peroxidation Marker (MDA), C - reactive protein, and leucocytes indices as Inflammatory Markers in Patients with Type 2 Diabetes Mellitus. International Journal of Advanced Research. 2 (1): 303-309.
  10. Farah Jabeen, Husan Afroz Rizvi and Anum Subhan.(2012): Effect of Hyperglycemia o Superoxide Dismutase Defense System and Erythrocyte Indices in Diabetic Patients. Pakistan journal of Biochemistry and Molecular biology.;45: (2).
  11. Farah Jabeen, Husan Afroz Rizvi, Farha Aziz, Yasmin Anjum (2013):Effect of Glycemic Control on Lipid Profile, Platelet Indices and Antioxidant Enzymes (Catalase and Superoxide dismutase Activities in Type 2 Diabetics. International Journal of Advanced Research. 1(7), 207-215.
  12. Farah Jabeen, Husan Afroz Rizvi, Rafia Azmat, Farha Aziz. (2013): Impairment of Glutathione metabolism and its impact on other Biochemical constituents in Patients of Diabetes Mellitus? J. Biochem. Mol. Biol.,; 46(3): 92-96.
  13. Fitzpatrick FA. (2004): Cyclooxygenase enzymes: Regulation and function. Curr Pharm Des.; 10(6): 577-588.
  14. Gillery P. (2001): Advanced glycation end products (AGES), free radicals and diabetes. J SocBiol; 195(4): 387-390.
  15. Grobbee DE.(2003) How to advance prevention of cardiovascular complications in type 2 diabetes. Metabolism.; 52(1):24-28.
  16. Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, Channon KM. (2002): Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation. 105(14): 1656-1662.
  17. Haffner SM.(1998) Management of dyslipidemia in adult with diabetes. Diabetes Care.; 21:1600-1678.
  18. Harris MI,( 1995): National Diabetes Data Group. National Institute of Health, Diabetes Digestive and Kidney Diseases. Diabetes in America, 2nd Ed., NIH (Publication No. 95-1468).:293-338.
  19. Harrison R.(2002): Structure and function of xanthine oxidoreductase: where are we now? Free Radic. Biol. Med.; 33 (6):774?797.
  20. Herrera E, Barbas C.(2001): Vitamin E: Action, metabolism and perspectives. J PhysiolBiochem.; 57(2): 43-56.
  21. Hille R.(2005): Molybdenum-containing hydroxylases. Arch. Biochem. Biophys.;433(1): 107? 116.
  22. Ido Y, Kilo C, Williamson JR.(1997): Cytosolic NADH/NAD+, free radicals, and vascular dysfunction in early diabetes mellitus. Diabetologia.; 40 (2): S115?S117.
  23. Imlay JA. (2003): Pathways of oxidative damage. Annual Review of Microbiology. 57: 395?418.
  24. Inoguchi T, Sonta T, Tsubouchi H, Etoh T, Kakimoto M, Sonoda N, et al. (2003): Protein Kinase C? dependent increase in Reactive Oxygen Species (ROS) production in vascular tissues of diabetes: Role of vascular NAD(P)H oxidase. J Am SocNephrol.; 14: 227?232.
  25. Jacob RA.(1995): The Integrated Antioxidant System. Nutr Res.; 15(5): 755-766.
  26. Janero DR. (1990): Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med.; 9: 515-540.
  27. Jiang F, Zhang Y and Dusting GJ. (2011): NADPH Oxidase-mediated redox signaling: Roles in Cellular stress response, stress tolerance, and tissue repair. Pharmacological Reviews.; 63 (1): 218-242.
  28. Johansen S J, Alex HK, Rychly DJ and Ergul A. (2005): Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice. Cardiovascular Diabetology. 4: 5-12.
 
  1. Johnson F, Giulivi C.(2005): Superoxide dismutases and their impact upon human health. Mol Aspects Med.; 26 (4-5):340-352.
  2. Kanner J, German JB, Kinsella JE. (1987): Initiation of lipid peroxidation in biological systems. Crit Rev Food SciNutr.; 25(4): 317-364.
  3. Kaur K., Bedi G, Kaur M, Anil Vij, Kaur I. (2008) Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease. Indian J Clin Biochem.; 23(1): 33?37.
  4. Klein R.(1995): Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care.; 18(2):258-268.
  5. Laura J, Niedernhofer J, Daniels S, Rouzer CA, Greene RE, Marnett L J. (2003): Malondialdehyde, a Product of lipid peroxidation, is mutagenic in human cells. J Biol Chem.; 278: 31426- 31433.
  6. Lenaz G. (2001): The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology. IUBMB Life,; 52(35): 159-164.
  7. Linster, CL, Van Schaftingen, E. (2007): Vitamin C. FEBS J.; 274 (1): 1?22.
  8. Maritim AC, Sanders RA, Watkings JB. (2002): Diabetes, Oxidative Stress and Antioxidants. J BiochemMolToxicol.; 17(1): 2-4.
  9. Maritim AC, Sanders RA, Watkins JB. (2003): Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J Nutr Biochem.; 14: 288?294.
  10. Marnett LJ. (1999): Lipid peroxidation-DNA damage by malondialdehyde. Mutation research. 424(1-2): 83-95.
  11. Mates JM, Perez-Gomez C and Nunez de Castro I. (1999): Antioxidant enzymes and human diseases. Clin. Biochem.: 32, 595-603.
  12. Meister A. (1988): Glutathione metabolism and its selective modification. J Biol Chem.; 263(17): 205?208.
  13. Meyer C, Dostou JM, Welle SL, Gerich JE. (2002): Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. Am J PhysiolEndocrinolMetab.; 282: 419-427.
  14. Mironova MA, Klein RL, Virella GT, Lopes-Virella MF. (2000): Modified LDL antibodies, LDL- containing immune complexes, and susceptibility of LDL to in vitro oxidation in patients with type 2 diabetes. Diabetes. 49: 1033-1041.
  15. Mullarkey CJ, Edelstein D, Brownlee M. (1990): Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes. BiochemBiophys Res Commun.; 173(3): 932?939.
  16. Niedowicz DM, Daleke DL. (2005): The role of oxidative stress in diabetic complications. Cell Biochem Biophys.; 43(2): 289-330.
  17. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, et al. (2000): Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. 404:787-790.
  18. Niwa Y. (1989): Lipid peroxides and superoxide dismutase (SOD) induction in skin inflammatory diseases and treatment with SOD preparations. Dermatologica.; 179 (1):101-106.
  19. Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, et al. (2003): Vitamin C as an antioxidant: Evaluation of its role in disease prevention. J Am CollNutr.; 22: 18?35.
  20. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, etal. (2008): Intensive blood glucose control andvascular outcomes in patients with type 2 diabetes. N Engl J Med.; 358(24): 2560-2572.
  21. Pazdro RR and Burgess JR. (2010): The role of vitamin E and oxidative stress in diabetes complications. Mech Ageing Dev.; 131(4): 276-286.
  22. Rains JL, Jain SK.(2011): Oxidative stress, insulin signaling, and diabetes. Free RadicBiol Med.; 50(5): 567-575.
  23. Rains JL, Jain SK. (2011): Oxidative stress, insulin signaling, and diabetes. Free RadicBiol Med.; 50(5): 567-575.
  24. Rhee SG. (2006): Cell Signaling: H2O2, a necessary evil for cell signaling. Science. 312 (5782): 1882?1883.
  25. Sakurai T, Tsuchiya S. (1988): Superoxide production from non-enzymatically glycated protein. FEBS Lett .; 236: 406-410.
  26. Setter SM, Campbell RK, Cahoon CJ. (2003): Biochemical pathways for microvascular complications of diabetes mellitus. Ann Pharmacother.; 37(12):1858-1866.
  27. Sharma R, Yang Y, Sharma A, Awasthi S, Awasthi Y. (2004): Antioxidant role of glutathione S transferases: Protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal.; 6 (2): 289?300.
  28. Shih KC, Kwak CF, Hwa CM. (1997): Acipimox attenuates hyper triglyceredemia in Dislipidemic Non-insulin dependent diabetes mellites patients without perturbation of insulin sensitivity and glycemic control. Diabetic. Res. clin. Pract.; 36(2): 113?119.
  29. Sies H. (1997): Oxidative stress: oxidants and antioxidants. Exp Physiol.; 82(2):291-295.
  30. Sies H. (1993): Strategies of antioxidant defense. Eur J Biochem.; 215:213-219.
  31. Soto C, Recoba R, Barron H, Alvarez C, Favari L. (2003): Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol.;136:205-212.
  32. Strazzullo P, Puig J. (2007): Uric acid and oxidative stress: Relative impact on cardiovascular risk. Nutr Metab Cardiovas Diseases.; 17 (6): 409?414.
  33. Suckling KE, Brian J. (1993): Animal models of human lipid metabolism. Prog. Lipid. Res.; 32:124.
  34. Suryawanshi NP, Bhutey AK, Nagdeote AN, Jadhav AA, Manoorkar GS. (2006): Study of lipid peroxide and lipid profile in diabetes mellitus. Indian J ClinBiochem.; 21(1): 126-130.
  35. Suzuki D, Miyata T, Saotome N, Horie K, Inagi R, Yasuda Y, et al. (1999): Immuno-histochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions. J Am SocNephrol.; 10(4): 822-832.
  36. Tainer JA. (1983): Structure and mechanism of copper, zinc superoxide dismutase. Nature.; (5940): 284?287.
  37. Tan Dun-Xian, Manchester, Lucien C, Reiter, Russel J, Qi, Wen-Bo, Karbownik, Malgorzata, Calvo, Juan R. (2000): Significance of melatonin in antioxidative defense system: Reactions and products. Neurosignals; 9 (3-4): 137-159.
  38. Tappel AL, (1973): Lipid peroxidation damage to cell components. ClinPathol. Fed Proce.;32(8): 1870-1874.
  39. Thompson CS. (2008): Animal models of diabetes mellitus: Relevance to vascular complications. Curr Pharm Des.; 14: 309-324.
  40. Van Dam PS. (2002): Oxidative stress and diabetic neuropathy: Pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev.; 18: 176-184.
  41. Vincent AM, Russell JW, Low P, Feldman EL. (2004): Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev.; 25: 612-628.
  42. Waggiallah H, Alzohairy M. (2011): The effect of oxidative stress on human red cells glutathione peroxidase, glutathione reductase level and prevalence of anemia among diabetics. North Am J Med Sci.; 3(7): 344-347.
  43. Wolff SP, Jiang ZY, Shunt JV. (1991): Protein glycation and oxidative stress in diabetic mellitus and Free Rad. Biol. Med.; 10: 339-352.
  44. Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. (1994): Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes.; 43: 1122?1129.
  45. Yamagishi S, Imaizumi T. (2005): Diabetic vascular complications: Pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des.; 11: 2279-2299.
  46. Zelko IN, Mariani TJ, Folz RJ. (2002): Superoxide dismutase multigene family: A comparison of theCuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Rad Biol Med.; 33: 337-349.

[Farah Jabeen, Farha Aziz and Husan Afroz Rizvi. (2017); OXIDATIVE STRESS, ANTIOXIDANT SCAVENGING SYSTEMS AND DIABETES MELLITUS: A CONCISE REVIEW. Int. J. of Adv. Res. 5 (Jul). 2205-2216] (ISSN 2320-5407). www.journalijar.com

Farah Jabeen
Chairperson/ Professor Department of Biochemistry Jinnah University for Women, 5-C Nazimabad, Karachi,

DOI:

Article DOI: 10.21474/IJAR01/4961      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4961

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