31Jul 2017

MEASLES VIRUS N AND P PROTEINS FIND INTERACTING PARTNERS IN HELA CELLS.

  • Applied Molecular Biology Laboratory, School of life Sciences, Jawaharlal Nehru University, New Delhi-110067, India.
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Measles, a contagious disease, is caused by measles virus with negative stranded non-segmented genome. The apoptotic property of N protein in human cancerous cell line is well established. Like any infectious agent, measles virus is expected to interact with certain molecules within the host cell in addition to surface receptors. We detected the binding partners of N and P proteins separately from cervical cancer cell line (HeLa) and checked by semi-quantitative real time PCR the gene expression affected by these interactions as well as the pathways with which the viral proteins interfere. Measles virus is an innately oncotropic virus. This interaction study by pull down assay will be helpful in elucidating their roles in cancer progression.

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[Sankhajit Bhattacharjee, Rishi Kumar Jaiswal and Pramod Kumar Yadava. (2017); MEASLES VIRUS N AND P PROTEINS FIND INTERACTING PARTNERS IN HELA CELLS. Int. J. of Adv. Res. 5 (Jul). 2691-2698] (ISSN 2320-5407). www.journalijar.com

Pramod Kumar Yadava
Applied Molecular Biology Laboratory, School of life Sciences, Jawaharlal Nehru University, New Delhi-110067, India.

DOI:

Article DOI: 10.21474/IJAR01/5012      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5012

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