ROLE OF METHOTREXATE INTOLERANCE SEVERITY SCORE (MISS) IN RHEUMATOID ARTHRITIS TO KNOW METHOTREXATE INTOLERANCE: A 2-YEAR PROSPECTIVE STUDY.

  • ParminderVirdi, Senior Resident, Department of Orthopedics, Sri Guru Ram Dass institute of medical sciences and research, Amritsar, India.
  • Professor,Department of Orthopedics, Sri Guru Ram Dass institute of medical sciences and research, Amritsar, India.
  • Medical student, Sri Guru Ram Dass institute of medical sciences and research, Amritsar, India.
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Rheumatoid Arthritis is the most common inflammatory arthritis among all other inflammatory arthritis. Methotrexate is the mainstay drug in treatment of RA. Objective: To determine the prevalence of methotrexate intolerance and importance of MISS as a tool to know methotrexate intolerance. Materials and Methods: 150 pts of RA including 120 females and 30 males attending rheumatoid services ofSri Guru Ram Dass hospital from December 2013 to December 2015 were prescribed methotrexate as per protocol approved and were followed for methotrexate intolerance using MISS (Methotrexate intolerance severity score). Results: Out of 150 pts of RA on methotrexate ,21 (14%) were found to have MISS >6. Conclusion: MISS is a very important tool for application in rheumatoid arthritis to know MTX intolerance and timely intervention to reduce the MTX intolerance to prevent the incompliance for an otherwise very effective DMARDS in treatment of rheumatoid arthritis.

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Parminder Virdi, Baljeet Singh and Randhirsingh. (2017); ROLE OF METHOTREXATE INTOLERANCE SEVERITY SCORE (MISS) IN RHEUMATOID ARTHRITIS TO KNOW METHOTREXATE INTOLERANCE: A 2-YEAR PROSPECTIVE STUDY., Int. J. of Adv. Res., 5 (07), 2542-2548, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/4995

Parminder virdi
Sri guru ram dass institution of medical sciences and research

DOI:

Article DOI: 10.21474/IJAR01/4995      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4995

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