22Aug 2017

CHITOSAN- CIPROFLOXACIN SCHIFF BASES: SYNTHESIS, CHARACTERIZATION AND IN VITROANTIMICROBIAL ACTIVITY EVALUATION.

  • Department of Polymeric Materials Research, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technology Applications, New Borg El-Arab City, 21934, Alex., Egypt.
  • Department of Chemistry, Faculty of Science, Ain Shams University, El-Abassia, Cairo, Egypt.
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In the present work, chitosan-ciprofloxacin Schiff bases (CHS-CFX-SB) containing azomethine group (?CH=N?) have been synthesized via condensing amino groups (NH2) of chitosan and carbonyl group (CO) of ciprofloxacin by using different molar ratios (0.05, 0.1, 0.25, 0.5 and 1) to enhance the antimicrobial activity of ciprofloxacin to offer a great potential for medical applications. The obtained CHS-CFX-SBs were structurally characterized using FT-IR and 1H NMR spectral analysis. Thus, the antimicrobial activities of these Schiff bases were assessed against six bacterial species, three gram-positive species (Methicillin resistant Staphylococcus aureus (MRSA), Streptococcus pyogenus and Streptococcus pneumoniae) and three gram-negative species (Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa) and one of fungus species; Candida albican by determining the microbial growth by measuring the inhibition zones in mm. The findings of this assessment showed that CHS-CFX-SB prepared by using equal molar ratio is having higher antibacterial activity against gram-positive bacteria than gram-negative ones. And thus, these chitosan derivatives have strong antibacterial activity against Staphylococcus aureus. Such Schiff bases had higher inhibitory efficiency against gram-positive bacteria than that of ciprofloxacin itself.

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[Emad A. Soliman, Ahmed I. Hashem and Ahmed R. Abou-zeid. (2017); CHITOSAN- CIPROFLOXACIN SCHIFF BASES: SYNTHESIS, CHARACTERIZATION AND IN VITROANTIMICROBIAL ACTIVITY EVALUATION. Int. J. of Adv. Res. 5 (Aug). 1147-1155] (ISSN 2320-5407). www.journalijar.com

Emad A. Soliman and Ahmed R. Abou-zeid
Department of Polymeric Materials Research, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technology Applications, New Borg El-Arab City, 21934, Alex., Egypt.

DOI:

Article DOI: 10.21474/IJAR01/5167      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5167

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