Vol. 5 (10) pp. 995-1002 DOI: 10.21474/IJAR01/5616

SYNERGISTIC ACTIVITY OF PLANT BASED BIOACTIVES IN COMBATING CANCER: AN OVERVIEW.

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  • Department of Biotechnology, Manav Rachna International University, Haryana-121004, India.
  • Accendere KMS, New Delhi-110044, India.
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Abstract

Cancer is one of the most prevalent diseases in the world having no measure for its complete cure once it reaches its mature stage. But it can be prevented by maintaining a healthy weight, eating plenty of green leafy vegetables, fruits and whole grains, being vaccinated against certain infectious diseases and avoiding too much exposure to UV radiations and carcinogens. The available treatments for cancer ranges from surgery to radiotherapy, chemotherapy, hormone therapy, biological therapies, and even bone marrow stem cell transplants, but they all possess some side effects and limitations. Hence, plant based bioactives and other natural therapies are gaining interest as novel means of cancer prevention and treatment. Polyphenols, isothiocyanates, anthocyanins, flavonoids, phytoestrogens etc. are some of the plant based bioactives having antioxidant efficacy thus are the prime targets of investigation for potencies against various ailments including cancer. However, in spite of the anticancer efficacies of plant based bioactives, a substantial prevention or cure of cancer has not been proposed till date. Hence, combinatorial drug therapy has been used which produces effects that are more than the effects predicted from their summated individual potencies, which is defined as synergy. Synergy is an abstract concept that refers to a result that arises from interacting processes in order to treat cancer and the synergistic activity can be analyzed by various means such as isobologram. In this review paper, available drug combinations targeting cancer, has been discussed with emphasis on plant based bioactives, their synergistic potential and mechanism of action. Moreover, the direction towards developing more effective combinations targeting cancer has also been highlighted.

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How to Cite This Article

Twinkle Gupta, Aarti Arora, Nilanjan Das and Sabiha Imran. (2017); SYNERGISTIC ACTIVITY OF PLANT BASED BIOACTIVES IN COMBATING CANCER: AN OVERVIEW., International Journal of Advanced Research (IJAR), 5 (10), 995-1002, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/5616

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Nilanjan Das
Accendere KMS

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