12Oct 2017

DIAGNOSTIC ALGORITHM AND TREATMENT FOR MICROSCOPIC COLITIS: A REVIEW.

  • Clinic of Gastroenterology, University Hospital ?Tsaritsa Yoanna ? ISUL?, Medical University Sofia, Sofia, Bulgaria.
  • Department of Pathology, University Hospital ?Aleksandrovska?, Medical University Sofia, Sofia, Bulgaria.
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Conflict of Interest The authors report no conflicts of interest and there is not include any sources of support (grants, support or other) for this work. Diagnostic algorithm and treatment for Microscopic Colitis: A Review Abstract: Microscopic colitis is an inflammatory bowel disorder characterized by chronic non-bloody watery diarrhea in patients with a macroscopically normal or near-normal colonic mucosa, affecting elderly population. The diagnosis depends on specific histological findings of the colonic mucosa. The prevalence of microscopic colitis in recent population-based studies is found in ~10?15% of patients with chronic watery diarrhoea. It is a benign condition that has been shown to severely impact health-related quality of life. The etiology and pathophysiology are still unknown. There is a growing hypothesis of an immune-mediated cause, supported by the close association of microscopic colitis with celiac disease, thyroid disease and others autoimmunity disorders. A meta-analysis of 6 randomized clinical trials showed clear benefit of budesonide in inducing clinical response and maintenance remission. Summary: At the present time, colonoscopy with multiple biopsies and histological analysis is the most important part of the diagnosis. However, there is a growing need for less-invasive procedures that can point out the diagnosis. A number of treatments are available for microscopic colitis, but only budesonide is well studied and effective for induction and maintenance treatment. This review focuses on the potential diagnostic tools and treatment algorithms of patients with microscopic colitis.

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[Ivan Aleksandrov Lyutakov, Plamen Ivanov Penchev and Diana Kyoseva. (2017); DIAGNOSTIC ALGORITHM AND TREATMENT FOR MICROSCOPIC COLITIS: A REVIEW. Int. J. of Adv. Res. 5 (Oct). 616-629] (ISSN 2320-5407). www.journalijar.com

Ivan Lyutakov
Clinic of Gastroenterology, University Hospital “Tsaritsa Yoanna – ISUL”, Medical University Sofia, Sofia, Bulgaria

DOI:

Article DOI: 10.21474/IJAR01/5567      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5567

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