CENTELLOSIDE CONTENT OF PEGAGAN (Centella asiatica) DELI SERDANG.
- Lecturer at Kopertis Region I (University of Sisingamangaraja XII Medan).
- Abstract
- Keywords
- References
- Cite This Article as
- Corresponding Author
Conservation efforts Centella asiatica and utilization of medicinal plants has been existing but very limited. Centella asiatica is not only harvested from the nature but also cultivated to obtain uniform quality. Saponins compound such as asiaticoside, madecassoside, asiaticacid and some chemichal content has already known. The study was conducted in lowland and highland of North Sumatera. The materials is pegagan accession from Deli Serdang. Tools used are waters alliance type of HPLC system, auto sampler 2695, photodiode array detector 996, coulomadsorbosphere C18 5μ, size 250 x 4.60 mm, UV absorbance, wavelength 210 nm, a flow rate 1.8 ml/min, injection volume 20 mL, and Empower Pro software. The results showed that the pattern of centelloside (asiaticoside, madecassoside and asiatic acid), when the content of one of bioactive compounds is high then otherwise be lower or biosynthetic pattern toward a compound needed. Age of Pegagan affect the content of centelloside. Centelloside pattern is influenced by growing medium condition and phosphorus content.
- Aziz, Z.A, M.R. Davey, J.B.Power, P. Anthony, R.M. Smith and K.C.Lowe. 2007. Production of asiaticoside and madecassoside in Centella asitica in vitro and in vivo. Plant Sciences Division, School of Biosciences, University of Nottingham,UK. Biologia Plantarum 51(1): 34-42.
- Bonfill, M.S., Rosa M. Cusid?, Lidia Osuna,M. Teresa Pi?ol, and Javier Palaz?n, 2006. ?Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. Biomed. Chromatography 20: 151-153
- Duke, J. 2005. Phytochemical and Etnobotanical Databases, Maryland, Beltsuille Agricultural Researah Center.
- Ghulamahdi, M., Sandra Arifin Aziz and Nurliani Bermawie. 2007. Evaluasi KarakterMorfologi Fisiologi dan Genetik Pegagan Mendukung Standarisasi Mutu Pegagan. Lab Balai Besar dan Pengembangan Pasca Panen, Lab PSPT IPB, Lab Pusa tStudi Biofarmaka IPB Lab Tanah IPB.
- Jain, Prateek K. and Ram K. Agrawal. 2008. High Performance Liquid Chromatographic Analysis of Asiaticoside in Centella asiatica (L.) Urban. Chiang Mai J. Sci. 2008; 35(3) : 521-525.
- Januwati, Mariam dan M. Yusron. 2005. Budidaya Tanaman Pegagan. Balai Penelitian dan Pengembangan Pertanian. Balai Penelitian Tanaman Obat dan Aromatika.
- H.L. 1977. Biochemistry of Steroids Hormones. London, Nlack Well Scientific Oxford Ikan.R. 1991. Natural Products to Laboratory Guide, 2nd edition, University of Jerusalem.
- P. 1981. Biosynthesis of Natural Products. Terjemahan PG Sammes, Chicster Ellis Horwood Ltd.
- Mangas, S., Merce Bonfill, Lidia Osuna, Elisabeth Moyano, Jaime Tortoriello, Rosa M. Cusido, M. Teresa Pin?ol, Javier Palazo?n. 2006. The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants. Phytochemistry 67: 2041-2049.
- Mangas, Susana, Elisabeth Moyano, Lidia Osuna, Rosa M. Cusido, Mercedes Bonfill, Javier Palazo. 2008. Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica Lett 30:1853-1859.
- Mangas S., Moyano E. Hernandez-Vazquez L. and Bonfill M. 2009. Centella asiatica (L) Urban: An updated approach Terpenoids. ISBN: 978-81-308-0332-6. Editors: Javier Palaz?n and Rosa M. Cusid?. Laboratorio de Fisiolog?a Vegetal. Facultad de Farmacia, Universidad de Barcelona, Spain.
- Matsuda H, Morikawa T, Ueda H, et al. Medicinal foodstuffs. XXVII. 2001. Saponin constituents of Pegagan (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centella saponins B, C, and D, from Centella asiatica cultivated in Sri Lanka [J]. Chem Pharm Bull 49(10): 1368-1371.
- Noverita, S. V., Luthfi M. Siregar and J.A. Napitupulu. 2012. Morphology of leaves and content of secondary metabolites asiaticoside in some accession of Pegagan (Centella asiatica Urban) in North Sumatera. Proceedings The 2nd Annual International Conference In conjunction with The 8th IMT-GT UNINET Bioscienes Conference, Life Sciences Chapter, ISSN : 2089 ? 208X (200-205).
- Noverita, S. V. dan Marline Nainggolan. 2012. Kandungan Asiaticoside dan Uji Fitokimia Daun Pegagan. Prosiding Seminar Nasional Farmasi 2012. Peranan Farmasi dalam Pembangunan Kesehatan. ISBN: 978-602-8892-72-8.
- Noverita, S. V. 2016. Production of Asiaticoside in Pegagan (Centella asiatica) with Phosphorus and Methyl Jasmonate Treatment. Global Journal For Research Analysis 5(9): 294-297.
- Vickery, Margaret L. and Brian Vickery. 1981. Secondary Plant Metabolism. University Park Press, Baltimore. Tim Kimia Organik. 2007. Penuntun Praktikum Kimia Organik II. FMIPA UNP, Padang.
[Noverita Sprinse Vinolina. (2017); CENTELLOSIDE CONTENT OF PEGAGAN (Centella asiatica) DELI SERDANG. Int. J. of Adv. Res. 5 (Oct). 1700-1704] (ISSN 2320-5407). www.journalijar.com
UNIVERSITAS SISINGAMANGARAJA XII