10Nov 2017

ANTICONVULSANT EFFECT OF ETHANOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM LINN. AND SODIUM VALPROATE - A COMPARATIVE STUDY IN ALBINO MICE.

  • Post graduate Junior Resident, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal.
  • Associate Professor, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal.
  • Post graduate Junior Resident, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal.
  • Professor, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal.
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This study was undertaken to compare the anticonvulsant property of ethanolic extract of Trigonella foenum graecum Linn. (TFG) plant and sodium valproate in albino mice by comparing the duration of hind limb tonic extension (HLTE) phase after maximal electroshock seizure (MES). Thirty albino mice of either sex weighing between 20-30g were screened and divided into 5 groups of 6 mice each. Group1(control) was given 1% gum acacia in distilled water at a volume of 2ml/100g body wt. orally. Group 3, 4 and 5 were given ethanolic extract of TFG at doses of 100, 200 and 400 mg/kg respectively. Group 2 (standard) was given sodium valproate - 300 mg/kg. All the drugs were suspended in 1% gum acacia solution and given at the volume of 2ml/100g/day orally. After 1 hour of drug administration, mice were subjected to MES by an electrical stimulus of 50mA of alternating current from an electro-convulsiometer for 0.2 sec via ear clip electrodes. Animal passed through various phases : tonic flexion, tonic extension, clonic convulsions, stupor, and recovery or death. Disappearance or shortening of hind limb tonic extension phase was taken as the percentage of protection. The data was analysed by one way ANOVA followed by Dunnett's 't' test and study showed significant anticonvulsant property of test drug as compared to standard.

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[Tarun Kumar, P.Shyamasakhi Devi, Priyotosh Banerjee and N. Meena Devi. (2017); ANTICONVULSANT EFFECT OF ETHANOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM LINN. AND SODIUM VALPROATE - A COMPARATIVE STUDY IN ALBINO MICE. Int. J. of Adv. Res. 5 (Nov). 350-354] (ISSN 2320-5407). www.journalijar.com

DR. P . SHYAMASAKHI DEVI
ASSOCIATE PROFESSOR

DOI:

Article DOI: 10.21474/IJAR01/5776      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5776

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