30Nov 2017

MEASUREMENT OF ZINC CONCENTRATION IN SERUM AND FOLLICULAR FLUID TO ASSESS ITS RELATION WITH OOCYTE AND EMBRYO QUALITY IN WOMEN UNDERGOING INTRA CYTOLASMIC SPERM INJECTION.

  • Lecture high institute for infertility diagnosis and assisted reproductive technologies , al-nahrain university, baghdad-iraq.
  • Prof. Dr collage of pharmacy, al-nahrain university, baghdad-iraq.
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Background: Zinc is part of over 300 metalloenzymes found in all metabolic pathways. It is required for DNA, RNA and protein synthesis, cell mediated immunity, reproduction, and development of the epidermis and CNS. Objectives: General population has relatively higher exposure to environmental pollution, the goal in this study is to assess the effect of Zinc concentration level in serum and follicular fluid on oocyte, embryo quality and pregnancy success in women undergoing ICSI. Patient, Materials and Methods: This study included 70 infertile couples joined in assisted reproductive technology (ART) programs to enter ICSI cycle in high Institute for Infertility Diagnosis and Assisted Reproductive Technologies and Kamal AL-Samarai Hospital, center of fertility and IVF(Baghdad/Iraq) during the period from October 2016 to February 2017. The level of Zinc concentration will be measured and assess their effect on oocyte and embryo quality. Results: No significant difference was observed in follicular fluid zinc (p- value 0.0859, P < 0.05) also there was No-significant difference was observed in serum zinc (P < 0.05) between pregnant and non- pregnant group. Serum zinc in pregnant group there was negatively correlated with (M2) type of oocyte, fertilization rate and number of embryo transfer but in no- pregnant group there was positive correlated with (M2) type of oocyte, fertilization rate and number of embryo transfer. Follicular fluid zinc in pregnant group shows negative correlated with M1, M2, rapture and abnormal type of oocyte, fertilization rate and number of embryo transfer and positive correlated with GV type. Follicular fluid zinc in pregnant group has negative correlated with fertilization rate and M2, GV type of oocyte and has positive correlated with number of embryo transfer and rapture, abnormal and M1 type of oocyte. Conclusions: There was no Significant difference in follicular fluid and serum zinc between pregnant and no?pregnant. The Increasing number of oocyte lead to increase the fertilization rate, high number of embryo transfer(grade1) this lead to increase chance of pregnancy outcome.

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[Muayyad S. Abbood, Shams A. Burhan and Nawal K. Al-Ani. (2017); MEASUREMENT OF ZINC CONCENTRATION IN SERUM AND FOLLICULAR FLUID TO ASSESS ITS RELATION WITH OOCYTE AND EMBRYO QUALITY IN WOMEN UNDERGOING INTRA CYTOLASMIC SPERM INJECTION. Int. J. of Adv. Res. 5 (Nov). 1333-1337] (ISSN 2320-5407). www.journalijar.com

Shams A.Burhan
High Institute for Infertility Diagnosis and Assisted Reproductive Technologies , Al-Nahrain University, Baghdad-IRAQ.

DOI:

Article DOI: 10.21474/IJAR01/5903      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5903

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