10Nov 2017

TO STUDY THE PREVALENCE OF PERIPHERAL NEUROPATHIES IN CASES OF HEPATITIS B & HEPATITIS C.

  • Junior Resident, Department of Medicine, Subharti Medical College, Meerut.
  • Professor, Department of Medicine, Subharti Medical College, Meerut.
  • Associate Professor, Department of Medicine, Subharti Medical College, Meerut.
  • Professor and Head, Department of Medicine, Subharti Medical College, Meerut.
Crossref Cited-by Linking logo

  • Abstract
  • References
  • Cite This Article as
  • Corresponding Author

Viral hepatitis B and C have become a major public health problem. Hepatitis B affects approximately 30% of world population with serological evidence of either current or past infection, hepatitis C virus infects approximately 3% of world population placing about 170 million people at risk of developing liver disease. Peripheral Neuropathy needs to be focused as it is important complication of cirrhosis of liver that may seriously impair patient\'s routine daily activities and quality of life. Peripheral nerve dysfunction is significantly more frequent in advanced liver disease compared with early liver damage. However, only few hepatologists really screen patients for PN due to time-consuming neurophysiological tests. Since treatment regimens are limited early diagnosis of is the most effective approach especially in resource restrained settings. Present study was aimed to study the association between neuropathy and Hepatitis B and Hepatitis C and to evaluate the incidence and character of peripheral neuropathy in patients with hepatitis B and hepatitis C.

  1. England JD, Asbury AK. Peripheral neuropathy. Lancet 2004; 363: 1251-61.
  2. Baha W, Foullous A, Dersi N, They-they TP, El alaoui K, Nourichafi N, et al. Prevalence and risk factors of hepatitis B and C virus infections among the general population and blood donors in Morocco. BMC Public Health. 2013; 13:50.
  3. Abraham P. Viral Hepatitis. India Clin Lab Med. 2012; 32(2):159-74.
  4. Phukan P. Compliance to occupational safety measures among the paramedical? workers in a tertiary hospital in Karnataka, South India. Int J Occup Environ Med. 2014;5(1):40-50.
  5. World Health Organization (WHO). Viral hepatitis - Report by the Secretariat.[Cited 2009 November 12]. [Accessed 2012 April 25]. Available from: http://apps.who.int/gb/ebwha/pdf_files/EB126/B126_15-en.pdf.
  6. Cacoub P, Renou C, Rosenthal E, et al. Extrahepatic manifestation of hepatitis C virus infection in 321 patients. Medicine (Baltimore) 2000; 79:47-56.
  7. Lidove O, Cacoub P, Maisonobe T, et al. Hepatitis C virus infection with peripheral neuropathy is not always associated with cryoglobulinaemia. Ann Rheum Dis 2001; 60:290-292.
  8. Cacoub P, Poynard T, Ghillani P, Charlotte F, Olivi M, Piette JC. Extrahepatic manifestations of chronic hepatitis. Arthritis Rheum 1999; 42:2204-2212.
  9. Lidove O, Maisonobe T, Servan J, et al. Peripheral neuropathy and hepatitis C virus infection: more than cryoglobulinemia. Rev Med Interne 2001; 22:939-947.
  10. Paoletti V, Donnarumma L, De MatteisA, et al. Peripheral neuropathy without cryoglobulinemia in patients with hepatitis C v?rus infection. Panminerva Med 2000; 42:175-178.
  11. De Martino L, Sampaolo S, Tucci C, et al. Viral RNAin nerve tissues of patients with hepatitis C infection and peripheral neuropathy. Muscle Nerve 2003; 27:102-104.
  12. Authier FJ, Bassez G, Payan C, et al. Detection of genomic viral RNA in nerve and muscle of patients with HCV neuro p a t h y. Neurology 2003; 60:808-812.
  13. Hou J, Liu Z, Gu F. Epidemiology and Prevention of Hepatitis B Virus Infection. Inter J Med Scie. 2005;2(1):50-7.
  14. Global surveillance and control of hepatitis C. Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Hepat. 1999;6:35-47.
  15. Acharya SK, Panda SK, Duphare H. Chronic hepatitis in a large Indian hospital. Natl Med J India. 1993;6:202-6.
  16. Keresztes K, Istenes I, Folhoffer A, Lakatos PL, Horvath A, Csak T, et al. Autonomic and sensory nerve dysfunction in primary biliary cirrhosis. World J Gastroenterol. 2004;10:3039?43.
  17. Kharbanda PS, Prabhakar S, Chawla YK, Das CP, Syal P. Peripheral neuropathy in liver cirrhosis. J Gastroenterol Hepatol. 2003;18:922?6.
  18. Chari VR, Katiyar BC, Rastogi BL, Bhattacharya SK. Neuropathy in hepatic disorders. A clinical, electrophysiological and histopathological appraisal. J Neurol Sci. 1977;31:93?111.
  19. Abraham P. Viral hepatitis in India. Clin Lab Med. 2012;32:159?174.
  20. Prevention of Hepatitis B in India ? An Overview. World Health Organization South-East Asia Regional Office; New Delhi: 2002.
  21. Sharma A, Singhal S, Mehta D, Dagar A. Prevalence of hepatitis B and C among patients admitted in respiratory medicine ward of a tertiary care hospital in Mullana, Ambala Haryana, India. Int J Res Med Sci 2017;5:1546-9.
  22. Kane A, Lloyd J, Zaffran M, Simonsen L, Kane M. Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates. Bulletin of the World Health Organization. 1999;77(10):801-7.

[Prayag Garg, Mukti Bhatnagar, S.K. Jha and S.K. Virmani. (2017); TO STUDY THE PREVALENCE OF PERIPHERAL NEUROPATHIES IN CASES OF HEPATITIS B & HEPATITIS C. Int. J. of Adv. Res. 5 (Nov). 359-363] (ISSN 2320-5407). www.journalijar.com

DR. PRAYAG GARG
1. Junior Resident, Department of Medicine, Subharti Medical College, Meerut

DOI:

Article DOI: 10.21474/IJAR01/5778      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5778

Download Full Paper

Download PDF No. of Downloads: 25 | No. of Views: 122