10Dec 2017

MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CLASSIFICATION ASPECTS OF SERRATED FORMATIONS OF THE LARGE INTESTINE.

  • Staff Scientist, Department of Pathology, Lomonosov Moscow State University, Russia (MD, PhD).
  • Post Graduate Student, Department of Pathology, Lomonosov Moscow State University, Russia (MD).
  • Professor and Head of Department of Pathology, Lomonosov Moscow State University, Russia (MD, PhD).
  • Senior Staff Scientist, Department of Pathology, Lomonosov Moscow State University, Russia (MD, PhD).
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Serrated formations of the colon in modern classification are divided into three main categories: hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), traditional serrated adenoma (TSA). Despite the existing difficulties, pathologists are encouraged to make every effort to identify SSA/P, since their potential malignancy is higher than that of HP. This work is devoted to the study of morphological characteristics of HP and SSA/P to clarify the possibilities of differential diagnostics and compare their potential malignancy based on the immunohistochemical profile (cdx2, beta-catenin, p53, ki67, claudin-1, -3, -4, CD44, Musashi-1). The results we obtained indicate the vague nature of the morphological differences between HP and SSA. The immunohistochemical profile does not differ between HP and SSA/P either. The nature of expression of most markers studied, indicates a lower potential malignancy of HP and SSA/P compared to TSA. The relatively high incidence of abnormal CDX2 expression suggests a significant role of alternative ways of HP and SSA/P malignization. TSA is fundamentally different from HP and SSA/P in immunophenotype, which may indicate both a higher potential malignancy of TSA and different ways of carcinogenesis of these types of polyps, despite their unification into a general group of ?serrated formations?.

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[Oleynikova N. A., Kharlova O. A, Mal`kov P. G. and Danilova N. V. (2017); MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL CLASSIFICATION ASPECTS OF SERRATED FORMATIONS OF THE LARGE INTESTINE. Int. J. of Adv. Res. 5 (Dec). 118-135] (ISSN 2320-5407). www.journalijar.com

Oleynikova N.A.
Lomonosov Moscow State University, Russia

DOI:

Article DOI: 10.21474/IJAR01/5946      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5946

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