Vol. 5 (12) pp. 1089-1098 DOI: 10.21474/IJAR01/6061

SUBACUTE TOXICITY AND HAEMATOLOGICAL PROFILES OF THE HYDRO-ETHANOL 70 % EXTRACT OF THE TRUNK BARKS OF TERMINALIA SUPERBA ENGL. AND DIELS (COMBRETACEAE) IN RATS.

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  • Laboratory of Physiology, Pharmacology and Pharmacopeia, Research-Training Unit of Sciences of Nature, University Nangui Abrogoua, 02 P. O. Box 801, Abidjan 02, C?te.d?Ivoire.
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Abstract

The aim of this study was to assess the safety of the hydro-ethanol 70 % extract of the trunk barks of Terminalia superba (HE 70 %) administered orally once daily for 28 days to three groups of albino rats at 250, 500 and 750 mg/kg body weight (b.w.) on haematological parameters and indices. The control group received distilled water while two other satellite groups (control and test group at 750 mg/kg b.w.) were added in order to study the reversibility. Blood was collected into EDTA tubes for haematology at day 0 and at the end of each week. Another 3 ml was collected from the satellite groups, 14 days after the end of the exposure period. These collected blood were used to analyze erythrocytic, leucocytic and thrombocytic profiles. HE 70 % extract does not have an effect on hematocrit, mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), white blood cells (leucocytes), lymphocytes, monocytes and granulocytes at all studied doses. On the other hand HE 70 % extract induced a significant increase in red blood cells and haemoglobins at the 4th week at 750 mg/kg b.w. and a significant reduction in mean corpuscular volume (MCV). The blood smear observation did not show any significant anomaly. As for the platelets they knew a significant reduction at all studied doses at the 4th week.This extract would be toxic for the platelets. But this toxicity was reversible.

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How to Cite This Article

Ndri Nguessan Mathieu, Goze Nomane Bernard, Kone Mama, Yao Kouadio Emile and Yapo Angoue Paul. (2017); SUBACUTE TOXICITY AND HAEMATOLOGICAL PROFILES OF THE HYDRO-ETHANOL 70 % EXTRACT OF THE TRUNK BARKS OF TERMINALIA SUPERBA ENGL. AND DIELS (COMBRETACEAE) IN RATS., Int. J. of Adv. Res., 5 (12), 1089-1098, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/6061

Corresponding Author

N dri N guessan Mathieu
Laboratory of Physiology, Pharmacology and Pharmacopeia, Research-Training Unit of Sciences of Nature, University Nangui Abrogoua, 02 P. O. Box 801, Abidjan 02, Côte.d’Ivoire
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.