25Dec 2017

PREVALENCE OF ORAL CANDIDIASIS AMONG DIABETICS - NON DIABETICS PATIENTS AND EVALUATETHE CONTRIBUTION OF RISKFACTORS IN IBB CITY.

  • Department of Biological Sciences and Medical Microbiology, Faculty of Science, Ibb University, Yemen.
  • Department of Science, Faculty of Education, Sana?a University, Sana?a, Yemen Republic.
  • Department of Biological Sciences, Faculty of Science, Ibb University, Yemen.
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Studies of oral fungal have indicated that prevalence of Candida was significantly higher in diabetics both in healthy controls and complete denture wearers compared to non -diabetics. The present investigation was carried out in the department of medical microbiology and clinical samples were collected through regular visits to three main hospitals Al-Noor, Al-Amean, Al-Thawra and diagnosis was in the ALFA medical laboratory in Ibb City during period from January into November 2016 .In the current study 70 oral swabs samples were collected from surfaces of the upper of oral cavity and denture of all patients and then placed into a test tube containing 5ml subouraud\'s dextrose broth. The positive sample was processed for Gram\'s staining, Germ tube test, Chlamydospores test, Carbohydrate utilization medium examination and Chromagar test was made for differentiation between Candida a species .The results in this study showed that prevalence of Candida oral infection in Ibb City was 36(52%) positive with oral candidiasis out of 70 samples studied while, 34(48%) of patients studied were negative with oral candidiasis. The results also showed the distribution of oral Candida infection among diabetes and non-diabetes patients was 29(41%) and 7(11%) respectively, this results concordant with many previous studies. Candida albicans was the most prevalent types of Candida a species in this study. The results in current investigation showed a significantly relationship between crews users, diabetes patients, age and oral candidiasis. Through, our study we recommending that many future studies with advanced diagnostics methods have to do for conformed our results.


  1. Alves, C.;Andion, J.;Brand?o, M. and Menezes, R. (2007). Pathogenic aspects of the periodontal disease associated to diabetes mellitus. Arq Bras EndocrinolMetab. 51:1050?7 .
  2. Aly, FZ.; Blackwell, CC.; Mackenzie, DAC. et al. (1995). Identification of oral yeast species isolated from individuals with diabetes mellitus. J.Mycoses. 38: 107-10.
  3. Abu-Elteen, KH. and Abu-Alteen, RM. (1998). The prevalence of Candida albicans populations in the mouths of complete denture wearers. New Microbiol. 21: 41-8.
  4. Akpan, A. and Morgan, R. (2002). Oral candidiasis. Postgrad Med J. 78: 455-9
  5. Agwu, E.; Ihongbe, JC.; McManus, BA.; Moran, GP.; Coleman, DC. and Sullivan, DJ. (2012). Distribution of yeast species associated with oral lesions in HIV-infected patients in South west Uganda. Med Mycol. 50 (3): 276-280.
  6. Bergendal, T.; Holmberg, K. and Nord, CE. (1979). Yeast colonization in the oral cavity and feces in patients with denture stomatitis. Acta Odontology Scand. 37:37-45.
  7. Bastiaan, RJ. and Reade, PC. (1982). The prevalence of Candida albicans in the mouths of tobacco smokers with and without oral mucous membrane keratoses. Oral Surg. 53:148-51.
  8. Bai, KY.; Reddy, CD. and Abu-Talib, SH. (1995). Oral candidal carriage in young insulin dependent diabetes mellitus. Indian SocPedodPrev Dent. 13:20-23.
  9. Cartwright, R.Y. (1976). A simple technique for observing germ tube formation in Candida albicans.Clin.pathol.29: 267-268.
  10. Darwazeh, AMG.; MacFarlane, TW.; McCuish, A. and et al. (1991). Mixed salivary glucose levels and candidal carriage in patients with diabetes mellitus. Oral PatholMed . 20: 280-3.
  11. Epstein, JB.; Pearsall, NN. and Truelove, EL. (1980). Quantitative relationships between Candida albicans in saliva and the clinical status of human subjects. J ClinMicrobiol. 12:475-76.
  12. Fenn, J.P.; Billetdeaux, E.; Segal, H.; Skodack-Jones, L.; Padilla, P.E.;? Bale, M.? Carroll, K. (1999). Comparison of four methodologies for rapid and cost-effective identification of Candida glabrata. J. Clin. Microbiol. 37: 3387-3389.
  13. Freydiere, A.M.; Parant, F.; Noel-Baron, F.; Crepy, M.; Treny, A.; Raberin, H.; Davidson, A. and Odd. F.C. (2002). Identification of Candida glabrataby a 30-second trehalase test. Clin. Microbiol.40: 3602-3605.
  14. Katiraee, F.; Khosravi, AR.; Khalaj, V.; Hajiabdolbaghi, M,;Khaksar, A. and Rasoolinejad, M. (2010). Oropharyngeal candidiasis and oral yeast colonization in Iranian Human Immuno deficiency Virus positive patients. Med Mycol. 20(1): 8-14.
  15. Loiselle, RJ.; Barnes, G. and Bahn, AN. (1964). The occurrence of Candida albicans in the oral cavity of diabetics. J Dent Res. 43:903.
  16. Mousavi, SAA.;Salari, S. Rezaie, S. Nejad, NS. Hadizadeh, S,;Kamyabi, H. and Aghasi, H. (2012). Identification of Candida species isolated from oral colonization in Iranian HIV-positive patients, by PCR-RFLP method. Jundishapur J Microbiol. 5(1): 336-340. DOI: 10.5812.
  17. Nanetti, A.; Stancari, F.; Ferri, M. et al. (1993). Relationship between Candida albicans and denture stomatitis: a clinical and microbiological study. Microbiological. 16: 287-92.
  18. Peters, RB.;Bahn, AN. and Barens, G. (1966). Candida albicans in the oral cavity of diabetics. J Dent Res 45:771.
  19. Peleg, AY.;Weerarathna, T.; McCarthy, JS. and Davis, TM. (2007). Common infections in diabetes: Pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 23:3?13.
  20. Powell, H.L.; Sand, C.A. and Rennie, R.P. (1998). Evaluation of CHROM agar Candida for presumptive identification of clinically important Candida Diagn. Microbio. Infect. Dis. 32: 201-204.
  21. Roberts, G.D.; Horst Meier, C.D.; Land, G.A. and Foxworth, J.H. (1978). Rapid urea broth test for yeasts. J.Clin.Microbiol.7: 584-588.
  22. Tapper-Jones, LM.;Aldred, MJ.; Walker, DM. and al. (1981). Candida infections and populations of Candida albicans in mouths of diabetics. Clin.Pathol. 34(7): 706-11.
  23. Ozturkcans, S.; Ozturkcan, S.; Akinci, S.; Bakici, MZ. andYalcin, N. (1993). Incidence of oral candidiasis in diabetic patients. Mikrobiyol Bul. 27:352-56.
  24. Willinger, B. and Manafi, M. (1999). Evaluation of CHROM agar Candida for rapid screening of clinical specimens for Candida species .J.Mycoses.42: 61-65.
  25. Yarahmadi, SH.; Khosravi, A.R.; Larijani, B. and et .al. (2002). Assessment of the fungal flora and the prevalence of fungal infections in the mouth of diabetics. Irn J. EndcorinolMetab 4:14.

[Abdullah Al-Mamari, Mohammed A. Al-Hegami, Naseem Al-Sophiany, Ebrahim Al-Zom, Wedad Al-Heeded, Ream Al-Atab, Yusef Al-Skary, Mona Ali, Tagreed Ali and Soaad Al-Wrafy. (2017); PREVALENCE OF ORAL CANDIDIASIS AMONG DIABETICS - NON DIABETICS PATIENTS AND EVALUATETHE CONTRIBUTION OF RISKFACTORS IN IBB CITY. Int. J. of Adv. Res. 5 (Dec). 1372-1380] (ISSN 2320-5407). www.journalijar.com


Dr.Abdullah Almamari
IBB UNIVERSITY,YEMEN REPUBLIC

DOI:


Article DOI: 10.21474/IJAR01/6096      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6096