VOGT-KOYANAGI-HARADA SYNDROME: CASE REPORT AND LITERATURE REVIEW.

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Introduction: Vogt-Koyanagi-Harada Syndrome is a cell-mediated autoimmune disease directed against melanocytes Leading to chronic multisystemic disease affecting the eye, inner ear, skin and meninges. VKH is a common disease in Kingdom of Saudi Arabia, accounting for 2.5?19.4% of all uveitis cases. Case report: A 24 years old male patient presented to our ophthalmology clinic with bilateral painless loss of vision for 3 days. With signs of bilateral conjunctival hyperemia, anisocoria, anterior chamber reaction, multiple focal exudative retinal detachments bilaterally associated with fundus edema. Discussion: VKH is a syndrome diagnosed clinically. It is unlikely presents with typical finding. Laboratory evidence must be involved to identify the disease and it?s possible causes.


  1. American Academy of Ophthalmology ? The Eye MD Association (2014): Vogt-Koyanagi-Harada syndrome; in Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis, chapter 6: Noninfectious (Autoimmune) Ocular Inflammatory Disease. San Francisco, AAO 2014. pp 183?190.
  2. Hatice Nida Sen, Janet Davis, Didar Ucar, Austin Fox, Chi Chao Chan & Debra A. Goldstein , Gender Disparities in Ocular Inflammatory Disorders , Current Eye Resrarch , Volume 40, 2015 ? Issue
  3. Read RW, Rechodouni A, Butani N, Johnston R, LaBree LD, Smith RE, et al. Complications and prog- nostic factors in Vogt-Koyanagi-Harada disease. Am J Ophthalmol 2001; 131: 599?606.
  4. Ohguro N, Sonoda KH, Takeuchi M, Matsumura M, Mochizuki M. The 2009 prospective multi-center epidemiologic survey of uveitis in Japan.?Jpn J Ophthalmol. 2012 Sep. 56(5):432-5
  5. fernando Arevalo , MD,Andres F. Lasave, MD,Vishali Gupta?, MD,Igor Kozak?, MD,Mosa Barakat Al Harbi?, MD,Abdulaziz Adel Al Rushood?, et all , Clinical Outcomes of Patients with Vogt ? Koyanagi ? Harada disease , Ocular Immunology and Inflammation , volume 24, 2016 ? lssue 5
  6. Read RW, Holland GN, Rao NA, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001;131:647?652
  7. Attia S, Khochtali S, Kahloun R, Zaouali S, Khairallah M. Vogt ? Koyanagi ? Harada disease. Expert Rev. Ophthalmol. 2012; 7(6):565-585
  8. Sunakawa M, Okinami S. Epstein-Barr virus-related antibody pattern in uveitis. Jpn J Ophthalmol. 1985. 29(4):423-8.
  9. Kanski Jack and Bowling Brad. Clinical Ophthalmology: A Systematic Approach, 7th Ed. El Sevier Saunders; 2011
  10. Accorinti?M; Pirraglia?MP; Corsi?C; Caggiano?C. Vogt-Koyanagi-Harada disease after head trauma. Eur J Ophthalmol. ?2007; 17(5):847-52
  11. Sober?AJ; Haynes?HA. Uveitis, poliosis, hypomelanosis, and alopecia in a patient with malignant melanoma. Arch Dermatol. 1978; 114(3):439-41
  12. Tabbara?KF. Vogt-Koyanagi-Harada syndrome after cutaneous injury. Ophthalmology. ?1999; 106(10):1854-5
  13. S. Al-Mezaine, D. Kangave, A.M. Abu El-AsrarPatterns of uveitis in patients admitted to a University Hospital in Riyadh, Saudi Arabia. Ocul Immunol Inflamm, 18 (6) (2010), pp. 424-43
  14. Nizamuddin SHM, Bawazeer AM. Pattern of Uveitis in Saudi Female Patients in Western Region of Saudi Arabia. JKAU Med. Sci. Vol. 19,no. 3, 2012, pp:73-83
  15. H. Hamade, N. Elkum, K.F. TabbaraCauses of uveitis at a referral center in Saudi Arabia. Ocul Immunol Inflamm, 17 (1) (2009), pp. 11-16
  16. M. Islam, K.F. TabbaraCauses of uveitis at the Eye Centre in Saudi Arabia: a retrospective review. Ophthalmic Epidemiol, 9 (4) (2002), pp. 239-249
  17. P?iv?nsalo-Hietanen T, Tuominen J, Vaahtoranta-Lehtonen H, Saari K. Incidence and prevalence of different uveitis entities in Finland. Acta Ophthalmol Scand 1997;75(1): 76-81.
  18. Rodriguez A, Calonge M, Pedroza-Seres M, Akova YA, Messmer EM, D?Amico DJ, Foster CS. Referral patterns of uveitis in a tertiary eye care centre. Arch Ophthalmol 1996;114(5): 593-599.
  19. Bawazeer AM, Nizamuddin SHM. Referral pattern of uveitis in a tertiary centre in western region of Saudi Arabia. Journal of Taibah University Medical Sciences Volume 8, Issue 1, 2013, Pages 24-30

[Nusaibah Musatafa Alhawsawi, Aisha Mohammed Alemam and Anas Mustafa Makhdoum. Muhammed Abdullah Fareed. (2018); VOGT-KOYANAGI-HARADA SYNDROME: CASE REPORT AND LITERATURE REVIEW. Int. J. of Adv. Res. 6 (Jan). 1109-1113] (ISSN 2320-5407). www.journalijar.com


Nusaibah Musatafa Alhawsawi
Department of Medicine , Taibah University Faculty of Medicine, Al Madinah Al Munawwarah , Kingdom of Saudi Arabia

DOI:


Article DOI: 10.21474/IJAR01/6327      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6327