08Jan 2018

CORRELATION BETWEEN MICROALBUMINURIA AND HBA1C AMONG TYPE2 DIABETIC PATIENTS IN JAMMU, J AND K STATE, INDIA.

  • Associate Professor, Deptt of Pathology, Acharya Shri Chander College of Medical Sciences.
  • Professor of Medicine, Acharya Shri Chander College of Medical Sciences.
  • Post graduate student, Deptt of Pathology, Acharya Shri Chander College of Medical Sciences.
  • Post graduate student, Deptt of Medicine, Acharya Shri Chander College of Medical Sciences.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

It has been noted that HbA1C levels are higher in diabetic patients, who develop micro- and macroalbuminuria. There is strong evidence that poor blood glucose control contributes to the development of albuminuria. Although the exact cause of this diabetic nephropathy is not clearly known but one of the reasons, considered to be a high risk factor, is hyperglycemia. Diabetic nephropathy has been known to lead to chronic kidney disease world wide, which in turn is responsible for 30-40 % end-stage renal disease (ESRD). The present study is based on 110 diabetics(70 males i.e. 63.6 % and 40 females i.e. 36.3 %), selected from patients attending both the outpatient department and those admitted, during the period from January to June 2017, in the Department of Medicine ASCOMS and Hospital, Sidhra , Jammu. The mean duration of diabetes was 8.70 ?5.4 years. The mean HbA1C was 7.91?0.95 and mean microalbumin was 92.81?65.4 mg/day. Our study revealed that out of 110 diabetic patients 25(22.72%) had HbA1C ≤ 7% and 85 (77.27%) had HbA1C ≥ 7%.Microalbuminuria was found in 65 (59.0%) patients out of which 5 (4.5%) patients had HbA1C ≤ 7% and 60 (54.5%) had HbA1C ≥7%, rest were normoalbuminuric. Patients having uncontrolled glycemic status with HbA1C ≥ 7% showed positive correlation with microalbuminuria > than 30 mg/day and this was confirmed by Pearsons Correlation Coefficient of r = 0.818, p value =0.001 and Chi Square Test. In addition Pearsons Correlation Analysis also showed statistically significant correlation of microalbuminuria with duration of diabetes, r = 0.622 and p<0.0001.

  1. Etienne G Krug.(2016):Trends in diabetes:sounding the alarm.Lancet.,387:1485-1486.
  2. International Diabetes Federation,IDF Diabetes Atlas, International Diabetes Federation, Brussels, Belgium,7thedition,
  3. 2015,http://www.diabetesatlas.org.
  4. Tobe SW, Mc Farlane PA, and Naimark DM.(2002): Microalbuminuria in diabetes mellitus. CMAJ.,167:499-503.
  5. Tang SC, Chan GC, and Lai KN.(2016): Recent advances in managing and understanding diabetic nephropathy.F1000Res.,5:?(Ekinci EI, Jerums G, Skene A,Crammer .
  6. De Boer IH, Rue TC, Hall YN, et al.(2011): Temporal trends in the prevalence of diabetic kidney disease in the United States.JAMA., 305(24):2532-9.
  7. Chowta NK, Pant P, Chowta MN.(2009):Microalbuminuria in diabetes mellitus: association with age, sex, weight and creatinine clearance. Indian J Nephrol.,19(2):53-56.
  8. Sanjeev Kumar, Aneja GK, Trivedi A, Atam V, Shankhwar SN, Panwar A, and Pradeep Kumar. (2014):Correlation of Diabetic Nephropathy and HbA1C in newly diagnosed Type 2 Diabetic Patients of Western UP.International Journal of Scientific and Research.Publications.,12(4): 2250 -2254.
  9. Tandon RK,Khare A,Gupta M,Nandwani S,Bansal R, and Sharma S.(2015):Relationship between glycosylated haemoglobin and risk of microalbuminuria in patients with Type 2 Diabetes Mellitus. Peoples Journal of Scientific Research.,1(8):14-18.
  10. Muraliswaran P, Aparna G, Kanagavalli P, and Srikath S.(2013):Prevalence of microalbuminuria in relation to HbA1C among known type 2 diabetic patients in Puducherry population.RJPBCS.,4(1):458-62.
  11. American Diabetes Association Diabetes Care?2014 Jan;?37(Supplement 1):?S81-S90.?https://doi.org/10.2337/dc14-S081).
  12. Ghai R, Verma ND, Goel A, Bhatnagar MK, Kapoor P, and Vashishta A.(1994) Microalbuminuria in non insulin dependent diabetes and essential hypertension:A marker of severe disease. J. Assoc. Physicians India., 42:771 -4.
  13. Kanakamani J, Ammini AC, Gupta N, and Dwivedi SN.(2010):Prevalence of microalbuminuria among patients with type 2 diabetes mellitus. Diabetes Technology and Therapeutics., 12(2):161-166.
  14. Maskari FA, Sadig ME, and Obineche E.(2008):Prevalence and determinants of microalbuminuria among diabetic patients in UAE.BMC Nephrology.,9:1. Available from:http://www.biomedcentral.com/1471- 2369/9/1.
  15. Nathan DM, Turgeon H, and Regan S.(2007): Diabetologia ., 50, 2239-2244 www.care.diabetes journals/contents/27/Suppl_1/s79-s8
  16. Park SB, Kim SS, Kim IJ, et al . (2017):Variability in glycated albumin levels predicts the progression of diabetic nephropathy.J Diabetes Complications., 3.
  17. Baig JA. (2017):Prevalence of microalbuminuria with relation to glycemic Research Gate.,Available from https://www.researchgate.net>publication.
  18. Gupta M, andSingh JP.(2017):Correlation of microalbuminuria with glycosylated haemoglobin in patients of diabetes having nephropathy.Int J Adv Med., 4(3):805- 808.
  19. Acharya K.Regmi S,Sapkota AS,Raut M, and Jha B.(2015):Microalbuminuria status in relation to glycated haemoglobin and duration of type 2 diabetes mellitus.ACCLM., 1(1):21-24.
  20. Verghese A,Deepa R, Rema M, and Mohan V.(2001):Frequency of proteinuria in type 2 diabetes mellitus seen at a diabetic centre in south India. Post grad Med J., 77:399-402.

[Bawana Raina, Puneeta Gupta, Nawaf Khurshid Sheikh and Kapil Gupta. (2018); CORRELATION BETWEEN MICROALBUMINURIA AND HBA1C AMONG TYPE2 DIABETIC PATIENTS IN JAMMU, J AND K STATE, INDIA. Int. J. of Adv. Res. 6 (Jan). 596-602] (ISSN 2320-5407). www.journalijar.com

Dr Puneeta Gupta
Professor of Medicine Acharya Shri Chander College Of Medical Sciences

DOI:

Article DOI: 10.21474/IJAR01/6261      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6261

Download Full Paper

Download PDF No. of Downloads: 71 | No. of Views: 324